Original Articles 2020

  1. Miyazawa K, Torii Y, Tabuchi M, Mizuno M, Yoshizako M, Minamoto C, Kawatani M, Osada H, Maeda H, Goto S.: Osteoclast inhibitors for bone fracture healing in mice with high-turnover osteoporosis.
    J Hard Tissue Biol, 29(4): 255-262 (2020) [ doi: 10.2485/jhtb.29.255 ]
  2. Shiroma Y, Fujita G, Yamamoto T, Takahashi RU, Kumar A, Zhang KYJ, Ito A, Osada H, Yoshida M, Tahara H.: Identification of a selective RelA inhibitor based on DSE-FRET screening methods.
    Int J Mol Sci, 21(23), E9150 (2020) PMID: 3 33266352 [ doi: 10.3390/ijms21239150 ]
  3. Nogawa T, Terai A, Amagai K, Hashimoto J, Futamura Y, Okano A, Fujie M, Satoh N, Ikeda H, Shin-Ya K, Osada H, Takahashi S.: Heterologous expression of the biosynthetic gene cluster for verticilactam and identification of analogues.
    J Nat Prod, 83(12): 3598-3605 (2020) PMID: 33216528 [ doi: 10.1021/acs.jnatprod.0c00755 ]
  4. Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.: Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
    Environ Pollut, 266(Pt 2): 115179 (2020) PMID: 32717636 [ doi: 10.1016/j.envpol.2020.115179 ]
  5. Sophonnithiprasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R.: Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress.
    Heliyon, 6(10): e05200 (2020) PMID: 33102840 [ doi: 10.1016/j.heliyon.2020.e05200 ]
  6. Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H.: Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics.
    Biosci Biotechnol Biochem, 84(12): 2484-2490 (2020) PMID: 32867616 [ doi: 10.1080/09168451.2020.1812375 ]
  7. Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.: A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
    Biosci Biotechnol Biochem, 84(10): 2113-2120 (2020) PMID: 32640867 [ doi: 10.1080/09168451.2020.1789445 ]
  8. Asai S, Tsunematsu Y, Masuya T, Otaka J, Osada H, Watanabe K.: Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete.
    J Antibiot, 73(10): 721-728 (2020) PMID: 32759961 [ doi: 10.1038/s41429-020-0355-9 ]
  9. Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J.: Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis.
    Aging (Albany NY), 12(14): 13991-14018 (2020) PMID: 32699185 [ doi: 10.18632/aging.103521 ]
  10. Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.: Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
    ACS Chem Biol, 15(8): 2195-2204 (2020) PMID: 32584541 [ doi: 10.1021/acschembio.0c00381 ]
  11. Yun CS, Nishimoto K, Motoyama T, Shimizu T, Hino T, Dohmae N, Nagano S, Osada H.: Unique features of the ketosynthase domain in a non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
    J Biol Chem, 295(33): 11602-11612 (2020) PMID: 32565425 [ doi: 10.1074/jbc.RA120.013105 ]
  12. Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.: β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.
    Sci Rep, 10(1): 10230 (2020) PMID: 32576869 [ doi: 10.1038/s41598-020-66974-y ]
  13. Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.: Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
    Sci Rep, 10(1): 8691 (2020) PMID: 32457324 [ doi: 10.1038/s41598-020-65614-9 ]
  14. Kato S, Motoyama T, Uramoto M, Nogawa T, Kamakura T, Osada H.: Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.
    J Antibiot, 73(7): 475–479 (2020) PMID: 32139880 [ doi: 10.1038/s41429-020-0295-4 ]
  15. Kato S, Motoyama T, Futamura Y, Uramoto M, Nogawa T, Hayashi T, Hirota H, Tanaka A, Takahashi-Ando N, Kamakura T, Osada H.: Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94.
    Biosci Biotechnol Biochem, 84(6): 1303-1307 (2020) PMID: 32043422 [ doi: 10.1080/09168451.2020.1725419 ]
  16. Tabuchi A, Fukushima-Sakuno E, Osaki-Oka K, Futamura Y, Motoyama T, Osada H, Ishikawa NK, Nagasawa E, Tokimoto K.: Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes.
    Biosci Biotechnol Biochem, 84(5): 876-886 (2020) PMID: 31942814 [ doi: 10.1080/09168451.2020.1714421 ]
  17. Minamoto C, Miyazawa K, Tabuchi M, Hirano M, Mizuno M, Yoshizako M, Torii Y, Asano Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.: Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice.
    Am J Orthod Dentofacial Orthop, 157(5): 680-689 (2020) PMID: 32354441 [ doi: 10.1016/j.ajodo.2019.04.037 ]
  18. Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang JH, Ahn JS.: CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells.
    J Microbiol Biotechnol, 30(1), 31-37 (2020) PMID: 31752054 [ doi: 10.4014/jmb.1908.08043 ]
  19. Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H: Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
    Bio-protocol: , 10, e3517 (2020) PMID: 33654742 [ doi: 10.21769/BioProtoc.3517 ]
  20. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N: Measurement of ATPase activity of valosin-containing protein/p97.
    Bio-protocol: , 10, e3516 (2020) PMID: 33654741 [ doi: 10.21769/BioProtoc.3516 ]
  21. Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.: Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
    Cell Chem Biol, 27(2), 186-196 (2020) PMID: 31813846 [ doi: 10.1016/j.chembiol.2019.11.010 ]