Original Articles 2003

  1. Ganesh, S., Tsurutani, N., Suzuki, T., Ueda, K., Lal. Agarwala, K., Osada, H., Delgado-Escueta, AV., and Yamakawa, K.
    The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain.
    Hum. Mol. Genet., 12, 2359-2368 (2003) PubMed

  2. Kakeya, H., Miyake, Y., Shoji, M., Kishida, S., Hayashi, Y., Kataoka, T., and Osada, H.
    Novel non-peptide inhibitors targeting death receptor-mediated apoptosis.
    Bioorg. Med. Chem. Lett., 13, 3743-3746 (2003) PubMed

  3. Shoji, M., Kishida, S., Kodera, Y., Shiina, I., Kakeya, H., Osada, H., and Hayashi, Y.
    Reaction modes of oxidative dimerization of epoxycyclohexenols.
    Tetrahedron Lett., 44, 7205-7207 (2003)

  4. Woehlecke, H., Osada, H., Herrmann, A., and Lage, H.
    Reversal of BCRP-mediated drug resistance by tryprostatin A.
    Int. J. Cancer, 107, 721-728 (2003) PubMed

  5. Kanoh, N., Kumashiro, S., Simizu, S., Kondoh, Y., Hatakeyama, S., Tashiro, H., and Osada, H.
    Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions.
    Angew. Chem. Int. Ed., 42, 5584-5587 (2003) PubMed

  6. Su, S., Kakeya, H., Osada, H., and J. A. Porco, J.
    Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides.
    Tetrahedron, 59, 8931-8946 (2003)

  7. Hayashi, Y., Shoji, M., Yamaguchi, S., Mukaiyama, T., Yamaguchi, J., Kakeya, H., and Osada, H.
    Asymmetric total synthesis of pseurotin A.
    Organic Lett., 5, 2287-2290 (2003) PubMed

  8. Sekiyama, Y., Palaniappan, N., Reynolds, KA., and Osada, H.
    Biosynthesis of phoslactomycins cyclohexane carboxylic acid as the starter unit.
    Tetrahedron, 59, 7465-7471 (2003)

  9. Palaniappan, N., Kim, BS., Sekiyama, Y., Osada, H., and Reynolds, KA.
    Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.
    J. Biol. Chem., 278, 35552-35557 (2003) PubMed

  10. Maruyama, M., Yagasaki, Y., Sudo, T., and Osada, H.
    Renal abnormalities in mice caused by insufficiency of of p38alpha.
    J. Recept. Signal Tr., 23, 173-183 (2003) PubMed

  11. Nakamura, M., Nakazawa, J., Usui, T., Osada, H., Kono, Y., and Takatsuki, A.
    Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.
    Biosci. Biotechnol. Biochem., 67, 151-157 (2003) PubMed

  12. Osada, H.
    Development and application of bioprobes for mammalian cell cycle analyses.
    Curr. Med. Chem., 10, 727-732 (2003) PubMed

  13. Simizu, S., Ishida, K., Wierzba, MK., Sato, TA., and Osada, H.
    Expression of heparanase in human tumor cell lines and human head and neck tumors.
    Cancer Lett., 193, 83-89 (2003) PubMed

  14. Nagashima, F., Kondoh, M., Kawase, M., Simizu, S., Osada, H., Fujii, M., Watanabe, Y., Sato, M., and Asakawa, Y.
    Apoptosis-inducing properties of ent-kaurene-type dterpenoids from the liverwort Jungermannia truncata.
    Planta Med., 69, 377-379 (2003) PubMed

  15. Kawatani, M., Uchi, M., Simizu, S., Osada, H., and Imoto, M.
    Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis.
    Exp. Cell Res., 286, 57-66 (2003) PubMed

  16. Miyake, Y., Kakeya, H., Kataoka, T., and Osada, H.
    Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in death-inducing signaling complex.
    J. Biol. Chem., 278, 11213-11220 (2003) PubMed

  17. Nakazawa, J., Yajima, J., Usui, T., Ueki, M., Takatsuki, A., Imoto, M., Toyoshima, YY., and Osada, H.
    A novel action of terpendole E on the motor activity of mitotic kinesin Eg5.
    Chem. Biol., 10, 131-137 (2003) PubMed

  18. Otsu, K., Yamashita, N., Nishida, K., Hirotani, S., Yamaguchi, O., Watanabe, T., Hikoso, S., Higuchi, Y., Matsumura, Y., Maruyama, M., Sudo, T., Osada, H., and Hori, M.
    Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.
    Biochem. Biophys. Res. Commun., 302, 56-60 (2003) PubMed