Original Articles 2006

  1. Uchimura, S., Oguchi, Y., Katsuki, M., Usui, T., Osada, H., Nikawa, J., Ishiwata, S., and Muto, E.
    Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin.
    EMBO J., 25, 5932-5941 (2006) PubMed

  2. Ueki, M., Galonic, DP., Vaillancourt, FH., Garneau-Tsodikova, S., Yeh, E., Vosburg, DA., Schroeder, FC., Osada, H., and Walsh, CT.
    Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.
    Chem. Biol., 13, 1183-1191 (2006) PubMed

  3. Usui, T., Nagumo, Y., Watanabe, A., Kubota, T., Komatsu, K., Kobayashi, J., and Osada, H.
    Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L.
    Chem. Biol., 13, 1153-1160 (2006) PubMed

  4. Taguchi, H., Ohkubo, A., Sekine, M., Seio, K., Kakeya, H., Osada, H., and Sasaki, T.
    Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.
    Nucleos. Nucleot. Nucl., 25, 647-654 (2006) PubMed

  5. Tomiki, T., Saito, T., Ueki, M., Konno, H., Asaoka, T., Suzuki, R., Uramoto, M., Kakeya, H., and Osada, H.
    RIKEN natural products encyclopedia.(RIKEN NPEdia), a chemical database of RIKEN natural products depository (RIKEN NPDepo).
    J. Comp. Aid. Chem., 7, 157-162 (2006)

  6. Kobayashi, Y., Mizunuma, M., Osada, H., and Miyakawa, T.
    Identification of saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells.
    Biosci. Biotechnol. Biochem., 70, 22451-22469 (2006) PubMed

  7. Kanoh, N., Asami, A., Kawatani, M., Honda, K., Kumashiro, S., Takayama, H., Shimizu, S., Amemiya, T., Kondoh, Y., Hatakeyama, S., Tsuganezawa, K., Utata, R., Tanaka, A., Yokoyama, S., Tashiro, H., and Osada, H.
    Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.
    Chem. Asian J., 1, 789-797 (2006) PubMed

  8. Matsuzawa, M., Kakeya, H., Yamaguchi, J., Shoji, M., Onose, R., Osada, H., and Hayashi, Y.
    Enantio-and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor,and biological properties of its new derivatives.
    Chem. Asian J., 1, 845-851 (2006) PubMed

  9. Okumura, H., Nakazawa, J., Tsuganezawa, K., Usui, T., Osada, H., Matsumoto, T., Tanaka, A., and Yokoyama, S.
    Phenothiazine and carpazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells
    Toxicol. Lett., 66, 44-52 (2006)

  10. Asami, Y., Kakeya, H., Okada, G., Toi, M., and Osada, H.
    RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.
    J. Antibiot., 59, 724-728 (2006) PubMed

  11. Hakamata, W., Muroi, M., Nishio, T., Oku, T., Takatsuki, A., Osada, H., Fukuhara, K., Okuda, H., and Kurihara, M.
    N-linked oligosaccharide processing enzymes as molecular targets for drug discovery.
    J.Appl.Glycosci., 53, 149-154 (2006)

  12. Watanabe, N., Nishihara, Y., Yamaguchi, T., Koito, A., Miyoshi, H., Kakaya, H., and Osada, H.
    Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.
    FEBS Lett., 580, 2598-2602 (2006) PubMed

  13. Li, W., Ju, J., Osada, H., and Shen, B.
    Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.
    J. Bacteriol., 188, 4148-4152 (2006) PubMed

  14. Kazami, S., Muroi, M., Kawatani, M., Kubota, T., Usui, T., Kobayashi, J., and Osada, H.
    Iejimalides, the antitumor 24-membered macrolides, are novel V-ATPases inhibitors.
    Biosci. Biotechnol. Biochem., 70, 1364-1370 (2006) PubMed

  15. Kanoh, N., Kyo, M., Inamori, K., Ando, A., Asami, A., Nakao, A., and Osada, H.
    SPR imaging measurement of photo-cross-linked small molecule microarrays on gold.
    Anal. Chem.,78, 2226-2230 (2006) PubMed

  16. Machida, K., Ohta, Y., and Osada, H.
    Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.
    J. Biol. Chem., 281, 14314-14320 (2006) PubMed

  17. Woo, J-T., Kawatani, M., Kato, M., Shinki, T., Yonezawa, T., Kanoh, N., Nakagawa, H., Takami, M., Lee, KH., Stern, PH., Nagai, K., and Osada, H.
    Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.
    Proc. Natl. Acad. Sci., USA., 103, 4729-4734 (2006) PubMed

  18. Temkin, V., Huang, Q., Liu, H., Osada, H., and Pope, RM.
    Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.
    Mol Cell Biol., 26, 2215-2225 (2006) PubMed

  19. Yamaguchi, J., Toyoshima, M., Shoji, M., Kakeya, H., Osada, H., and Hayashi, Y.
    Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin.
    Angew. Chem. Int. Ed., 46, 789-793 (2006) PubMed

  20. Shiina, I., Uchimaru, T., Shoji, M., Kakeya, H., Osada, H., and Hayashi, Y.
    Computational study on the reaction mechanism of the key thermal [4+4] cycloaddition reaction in the biosynthesis of epoxytwinol A.
    Organic Lett., 8, 1041-1044 (2006) PubMed