Original Articles 2000

  1. Hamaguchi T, Takahashi A, Kagamizono T, Manaka A, Sato M, Osada H.: Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.
    Bioorg Med Chem Lett, 10(23): 2657-2660 (2000) PMID: 11128645 [ doi: 10.1016/s0960-894x(00)00539-4 ]
  2. Simizu S, Osada H.: Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines.
    Nat Cell Biol, 2(11): 852-854 (2000) PMID: 11056542 [ doi: 10.1038/35041102 ]
  3. Watabe M, Machida K, Osada H.: MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria.
    Cancer Res, 60(18): 5214-5222 (2000) PMID: 11016650 [ url ]
  4. Maruyama M, Sudo T, Kasuya Y, Shiga T, Hu B, Osada H.: Immunolocalization of p38 MAP kinase in mouse brain.
    Brain Res, 887(2): 350-358 (2000) PMID: 11134625 [ doi: 10.1016/s0006-8993(00)03063-8 ]
  5. Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M.: Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL).
    J Biol Chem, 275(40): 31155-31161 (2000) PMID: 10859303 [ doi: 10.1074/jbc.M001229200 ]
  6. Ganesh S, Agarwala KL, Ueda K, Akagi T, Shoda K, Usui T, Hashikawa T, Osada H, Delgado-Escueta AV, Yamakawa K.: Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes.
    Hum Mol Genet, 9(15): 2251-2261 (2000) PMID: 11001928 [ doi: 10.1093/oxfordjournals.hmg.a018916 ]
  7. Watanabe H, Watanabe H, Usui T, Kondoh M, Osada H, Kitahara T.: Synthesis of pironetin and related analogs: studies on structure-activity relationships as tubulin assembly inhibitors.
    J Antibiot, 53(5): 540-545 (2000) PMID: 10908119 [ doi: 10.7164/antibiotics.53.540 ]
  8. Ko HR, Kim BY, Oh WK, Kang DO, Lee HS, Koshino H, Osada H, Mheen TI, Ahn JS.: CRM646-A and -B, novel fungal metabolites that inhibit heparinase.
    J Antibiot, 53(2): 211-214 (2000) PMID: 10805586 [ doi: 10.7164/antibiotics.53.211 ]
  9. Sudo T, Maruyama M, Osada H.: p62 functions as a p38 MAP kinase regulator.
    Biochem Biophys Res Commun, 269(2): 521-525 (2000) PMID: 10708586 [ doi: 10.1006/bbrc.2000.2333 ]
  10. Watabe M, Kakeya H, Onose R, Osada H.: Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
    J Biol Chem, 275(12): 8766-8771 (2000) PMID: 10722720 [ doi: 10.1074/jbc.275.12.8766 ]
  11. Sanz-Cervera JF, Stocking EM, Usui T, Osada H, Williams RM.: Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro.
    Bioorg Med Chem, 8(10): 2407-2415 (2000) PMID: 11058035 [ doi: 10.1016/s0968-0896(00)00171-1 ]
  12. Wang H, Usui T, Osada H, Ganesan A.: Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.
    J Med Chem, 43(8): 1577-1585 (2000) PMID: 10780915 [ doi: 10.1021/jm9905662 ]
  13. Kawatani M, Simizu S, Osada H, Takada M, Arber N, Imoto M.: Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis.
    Exp Cell Res, 259(2): 389-397 (2000) PMID: 10964506 [ doi: 10.1006/excr.2000.4986 ]
  14. Simizu S, Shibasaki F, Osada H.: Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells.
    Jpn J Cancer Res, 91(7): 706-714 (2000) PMID: 10920278 [ doi: 10.1111/j.1349-7006.2000.tb01003.x ]