Original Articles 2008

  1. Yano, A., Tsutsumi, S., Soga, S., Lee, MJ., Trepel, J., Osada, H., and Neckers, L.
    Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
    Proc. Natl. Acad. Sci. USA., 105, 15541-15546 (2008) PubMed

  2. Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., and Osada, H.
    Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II.
    Biosci. Biotechnol. Biochem., 72, 2739-2749 (2008) PubMed

  3. Hiraoka, K., Zenmyo, M., Watari, K., Iguchi, H., Fotovati, A., Kimura, YN., Hosoi, F., Shoda, T., Nagata, K., Osada, H., Ono, M., and Kuwano, M.
    Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.
    Cancer Sci., 99, 1595-1602 (2008) PubMed

  4. Li, W., Ju, J., Rajski, SR., Osada, H., and Shen, B.
    Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.
    J. Biol. Chem., 283, 28607-28617 (2008) PubMed

  5. Kawatani, M., Okumura, H., Honda, K., Kanoh, N., Muroi, M., Dohmae, N., Takami, M., Kitagawa, M., Futamura, Y., Imoto, M., and Osada, H.
    The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.
    Proc Natl Acad Sci U S A. , 105, 11691-11696 (2008) PubMed

  6. Lai, NS., Simizu, S., Morisaki, D., Muroi, M., and Osada, H.
    Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.
    Exp. Cell Res., 314, 2834-2845 (2008) PubMed

  7. Hayashi, Y., Shoji, M., Ishikawa, H., Yamaguchi, J., Tamura, T., Imai, H., Nishigaya, Y., Takabe, K., Kakeya, H., and Osada, H.
    The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug.
    Angew Chem Int Ed Engl., 47, 6657-6660 PubMed

  8. Saito, A., Kawai, K., Takayama, H., Sudo, T., and Osada, H.
    Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase.
    Chem Asian J., 3, 1607-1612 (2008) PubMed

  9. Asami, Y., Kakeya, H., Komi, Y., Kojima, S., Nishikawa, K., Beebe, K., Neckers, L., and Osada, H.
    Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.
    Cancer Sci. , 99, 1853-1858 (2008) PubMed

  10. Kamiyama, H., Usui, T., Sakurai, H., Shoji, M., Hayashi, Y., Kakeya, H., and Osada, H.
    Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.
    Biosci Biotechnol Biochem., 72, 1894-1900 (2008) PubMed

  11. Shimizu, T., Usui, T., Fujikura, M., Kawatani, M., Satoh, T., Machida, K., Kanoh, N., Woo, JT., Osada, H., and Sodeoka, M.
    Synthesis and biological activities of reveromycin A and spirofungin A derivatives.
    Bioorg Med Chem Lett., 18, 3756-3760 (2008) PubMed

  12. Jain, HD., Zhang, C., Zhou, S., Zhou, H., Ma, J., Liu, X., Liao, X., Deveau, AM., Dieckhaus, CM., Johnson, MA., Smith, KS., Macdonald, TL., Kakeya, H., Osada, H., and Cook, JM.
    Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
    Bioorg Med Chem. , 16, 4626-4651 (2008) PubMed

  13. Kamiyama, H., Usui, T., Uramoto, M., Takagi, H., Shoji, M., Hayashi, Y., Kakeya, H., and Osada, H.
    Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.
    J. Antibiot., 61, 94-97 (2008) PubMed

  14. Kawai, K., Saito, A., Sudo, T., and Osada, H.
    Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.
    J. Biochem., 143, 765-772 (2008) PubMed

  15. Kamiyama, H., Kakeya, H., Usui, T., Nishikawa, K., Shoji, M., Hayashi, Y., and Osada, H.
    Epoxyquinol B shows antiangiogenic effects in vitro and in vivo by inhibiting not only VEGFR2 but also EGFR, FGFR, and PDGFR.
    Oncol. Res., 17, 11-21 (2008)

  16. Sato, Y., Kamiyama, H., Usui, T., Saito, T., Osada, H., Kuwahara, S., and Kiyota, H.
    Synthesis and anti-angiogenic activity of cortistatin analogs.
    Biosci. Biotechnol. Biochem. 72, 2992-2997 (2008) PubMed