Original Articles before 1999

  1. Watabe, M., Kakeya, H., and Osada, H.
    Requirement pf protein kinase (Krs/MST) activation for MT-21-induced apoptosis.
    Oncogene, 18, 5211-5220 (1999)

  2. Kakeya, H., Morishita, M., Koshino, H., Morita, T., Kobayashi, K., and Osada, H.
    Cytoxazone, A novel cytokine modulator containing a 2-oxazolidinone ring produced by Streptomyces sp.
    J. Org. Chem. , 64, 1052-1053 (1999)

  3. Kondoh, M., Usui, T., Nishikiori, T., Mayumi, T., and Osada, H.
    Apoptosis induction via microtubule disassembly by an antitumor compound, pironetin.
    Biochem. J. , 340, 411-416 (1999)

  4. Kagamizono, T., Hamaguchi, T., Ando, T., Sugawara, K., Adach, T., and Osada, H.
    Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.
    J. Antibiot. , 52, 75-80 (1999)

  5. Usui, T., Marriott, G., Inagaki, M., Schwarp, G., and Osada, H.
    Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.
    J. Biochem. , 125, 960-965 (1999)

  6. Togashi, K., Kakeya, H., Morishita, M., Song, Y-X., and Osada, H.
    Inhibition of human telomerase activity by alterperylenol.
    Oncol. Res. , 10, 449-453 (1998)

  7. Kimura, K., Ikeda, Y., Kagami, S., Yoshihama, M., Suzuki, K., Osada, H., and Isono, K.
    Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins.
    J. Antibiot. , 51, 1099-1104 (1998)

  8. Uchida, K., Watanabe, H., Usui, T., Osada, H., and Kitahara, T.
    Syntheses and bioactivities of acetophthalidin and its derivatives.
    Heterocycles , 48, 2049-2060 (1998)

  9. Kakeya, H., Morisita, M., Ikeno, A., Kobinata, K., Yano, T., and Osada, H.
    Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus.
    J. Antibiot. , 51, 963-966 (1998)

  10. Kakeya, H., Onose, R., and Osada, H.
    Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
    Cancer Res. , 58, 4888-4894 (1998)

  11. Kondoh, M., Usui, T., Mayumi, T., and Osada, H.
    Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ.
    J. Antibiot. , 51, 801-804 (1998)

  12. Kakeya, H., Onose, R., Liu, PC., Onozawa, C., Matsumura, F., and Osada, H.
    Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic.
    Cancer Res. , 58, 704-710 (1998)

  13. Kakeya, H., Morishita, M., Kobinata, K., Osono, M., Ishizuka, M., and Osada, H.
    Isolation and biological activity of a novel cytokine modulator, cytoxazone.
    J. Antibiot. , 51, 1126-1128 (1998)

  14. Kimura, K., Kagami, S., Ikeda, Y., Takahashi, H., Yoshihama, M., Kusakabe, H., Osada, H., and Isono, K.
    New type of liposidomycin that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.
    J. Antibiot. , 51, 640-646 (1998)

  15. Kimura, K., Ikeda, Y., Kagami, S., Yoshihama, M., Ubukata, M., Esumi, Y., Osada, H., and Isono, K.
    New type of liposidomycin that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.
    J. Antibiot. , 51, 647-654 (1998)

  16. Zhang, H-P., Kakeya, H., and Osada, H.
    Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.
    Tetrahedron Lett. , 39, 6947-6948 (1998)

  17. Usui, T., Kondoh, M., Cui, C-B., Mayumi, T., and Osada, H.
    Tryprostatin A, a specific and novel inhibitor of microtubule assembly.
    Biochem. J. , 333, 543-548 (1998)

  18. Kondoh, M., Usui, T., Kobayashi, S., Tsuchiya, K., Nishikawa, K., Nishikiori, T., Mayumi, T., and Osada, H.
    Cell cycle arrest and antitumor activity of pironetin and its derivatives.
    Cancer Lett. , 126, 29-32 (1998)

  19. Kakeya, H., Zhang, H-p., Kobinata, K., Onose, R., Onozawa, C., Kudo, T., and Osada, H.
    Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
    J. Antibiot. , 50, 370-372 (1997)

  20. Zhang, H., Kakeya, H., and Osada, H.
    Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells.
    Tetrahedron Lett. , 38, 1789-1792 (1997)

  21. Takahashi, H., Yamashita, Y., Takaoka, H., Nakamura, J., Yoshihama, M., and Osada, H.
    Inhibitory action of reveromycin A on TGF-alpha-dependent growth of ovarian carcinoma BG-1 in vitro and in vivo.
    Oncol. Res. , 9, 7-11 (1997)

  22. Hamaguchi, T., Masuda, A., Morino, T., and Osada, H.
    Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases.
    Chem. Biol. , 4, 279-286 (1997)

  23. Matsumura, F., Enan, E., Dunlap, DY., Wu, Z., and Osada, H.
    Absence of selected signs of toxicity from TCDD-treated, c-src deficient mice.
    Organohalogen Compounds , 34, 292-295 (1997)

  24. Kakeya, H., Morishita, M., Onozawa, C., Usami, R., Horikoshi, K., Kimura, K., Yishihama, M. and Osada, H.
    RKS-1778, a new mammalian cell cycle inhibitor and a key intermediate of the [11]cytochalasin group.
    J. Nat. Prod. , 60, 669-672 (1997)

  25. Yagi, M., Kato, S., KobaYashi, Y., Kubo, K., Shimizu, T., Nishitoba, T., Isoe, T., Nakamura, K., Ohashi, H., Kobayashi, N., Iinuma, N., Onose, R., Osada, H., and Osawa, T.
    Selective inhibition of platelet-derived growth factor (PDGF) receptor autophosphorylation and PDGF-mediated cellular events by a quinoline derivative.
    Exp. Cell Res. , 234, 285-292 (1997)

  26. Muroi, M., Kimura, K-.i, Osada, H., Inukai, M., and Takatsuki, A.
    Liposidomycin B inhibits in vitro formation of polyprenyl (pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis.
    J. Antibiot. , 50, 103-104 (1997)

  27. Cui, C-B., Kakeya, H., and Osada, H.
    Novel mammalian cell cycle inhibitors, cyclotryprostatins A-D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M Phase.
    Tetrahedron, 53, 59-72 (1997)

  28. Yao, R., Yoshihara, M., and Osada, H.
    Specific activation of a c-Jun NH2 terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine.
    J. Biol. Chem. , 272, 18261-18266 (1997)

  29. Kagamizono, T., Sakai, N., Arai, K., Kobinata, K., and Osada, H.
    Terpeptin, A novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1.
    Tetrahedron Lett. , 38, 1223-1226 (1997)

  30. Yao, R., and Osada, H.
    Induction of neurite outgrowth in PC12 cells by ノ。-lactam-related compounds via Ras-MAP kinase signaling pathway independent mechanism.
    Exp. Cell Res. , 234, 233-239 (1997)

  31. Kakeya, H., Onozawa, C., Sato, M., Arai, K., and Osada, H.
    Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high affinity nerve growth factor receptors.
    J. Med. Chem. , 40, 391-394 (1997)

  32. Osada, H., Cui, C-B., Onose, R., and Hanaoka, F.
    Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210.
    Bioorg. Med. Chem. , 5, 193-203 (1997)

  33. Ubukata, M., Morita, T-i., Kakeya, H., Kobinata, K., Kudo, T., and Osada, H.
    Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity.
    J. Antibiot. , 49, 1096-1100 (1996)

  34. Shimizu, T., Kobayashi, R., Osako, K., Osada, H., and Nakata, T.
    Synthetic studies on reveromycin A, stereoselective synthsis of the spiroketal system.
    Tetrahedron Lett. , 37, 6755-6758 (1996)

  35. Cui, C-B., Kakeya, H., and Osada, H.
    Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M Phase.
    Tetrahedron , 52, 12651-12666 (1996)

  36. Sodeoka, M., Sampe, R., Kagamizono, T., and Osada, H.
    Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities.
    Tetrahedron Lett. , 37, 8775-8778 (1996)

  37. Sudo, T., Shinohara, K., Dohmae, N., Takio, K., Usami, R., Horikoshi, K., and Osada, H.
    Isolation and characterization of the gene encoding an aminopeptidase from Xanthomonas campestris pv. citri.
    Biochem. J. , 319, 99-102 (1996) PubMed

  38. Cui, Z., Hirata, D., Tsuchiya, E., Osada, H., and Miyagawa, T.
    The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad rang of organic anions.
    J. Biol. Chem. , 271, 14712-14716 (1996)

  39. Cui CB, Kakeya H, Osada H.: Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus.
    J Antibiot, 49 (8): 832-835 (1996) PMID: 8823522
  40. Cui, C-B., Kakeya, H., and Osada, H.
    Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures.
    J. Antibiot. , 49, 534-540 (1996)

  41. Cui, C-B., Kakeya, H., Okada, G., Onose, R., and Osada, H.
    Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus I. Taxonomy, fermentation, isolation and biological properties.
    J. Antibiot. , 49, 527-533 (1996)

  42. Isogai, Y., Tsuyama, T., Osada, H., Iizuka, T., and Tanaka, K.
    Direct measurement of oscillatory generation of superoxide anions by single phagocytes.
    FEBS Lett. , 380, 263-266 (1996)

  43. Nishiyama, U., Ubukata, M., Magae, J., Kataoka, T., Erdodi, F., Hartshorne, DJ., Isono, K., Nagai, K., and Osada, H.
    Structure-activity relationship within a series of degradation products of tautomycin.
    Biosci. Biotechnol. Biochem., 60, 103-107 (1996)

  44. Ubukata, M., Morita, T-I., Uramoto, M., and Osaada, H.
    Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. II. Isolation, physico-chemical properties and structure elucidation.
    J. Antibiot., 49, 65-70 (1996)

  45. Matsuura, M., Onose, R., and Osada, H.
    Morphology reversion activity of phosmidosine and phosmidosine B, a newly isolated derivative, on src transformed NRK cells.
    J. Antibiot. , 49, 361-365 (1996)

  46. Cui CB, Ubukata M, Kakeya H, Onose R, Okada G, Takahashi I, Isono K, Osada H.: Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment.
    J Antibiot, 49 (2): 216-219 (1996) PMID: 8621365
  47. Cui CB, Kakeya H, Okada G, Onose R, Ubukata M, Takahashi I, Isono K, Osada H.: Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.
    J Antibiot, 48 (11): 1382-1384 (1995) PMID: 8557590
  48. Rani, BR., Cui, C-B., Ubukata, M., and Osada, H.
    Thiazoline analogues of epiderstatin, new inhibitors of cell cycle of tsFT-210 cells.
    J. Antibiot., 48, 1179-1181 (1995)

  49. Ubukata, M., Rani, RB., Cui, C-B., and Osada, H.
    Preparation of optically active epiderstatin and its stereoisomers - epiderstatin is not a real inhibitor of the mitogenic activity induced by epidermal growth factor.
    J. Antibiot., 48, 1176-1178 (1995)

  50. Ubukata, M., Shiraishi, N., Kobinata, K., Kudo, T., Yamaguchi, I., and Osada, H.
    RS-22A, B and C, new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, Isolation and Biological activities.
    J. Antibiot., 48, 289-292 (1995)

  51. Ubukata, M., Morita, T., and Osada, H.
    RS-22A, B and C, new macrolide antibiotics from streptomyces violaceusniger. II. Physico-chemical properties and structure elucidation.
    J. Antibiot., 48, 293-299 (1995)

  52. Kakeya, H., Takahashi, I., Okada, G., Isono, K., and Osada, H.
    Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.
    J. Antibiot. , 48, 733-735 (1995)

  53. Koshino, S., Koshino, H., Matsuura, N., Kobinata, K., Onose, R., Isono, K., and Osada, H.
    A new cyclic lipopeptide antibiotic,enamidonin.
    J. Antibiot. , 48, 185-187 (1995)

  54. Fujii, S., Kato, H., Furuse, H., Ito, K., Osada, H., Hamaguchi, T., and Kuroda, Y.
    The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons.
    Neurosci. Lett. , 187, 130-132 (1995)

  55. Fujii, S., Ito, K., Osada, H., Hamaguchi, T., Kuroda, Y., and Kato, H.
    Extracellular phosphorylation of membrane protein modifies theta burst-induced long-term potentiation in CA1 neurons of guinea-pig hippocampal slices.
    Neurosci. Lett. , 187, 133-136 (1995)

  56. Hamaguchi, T., Sudo, T. and Osada, H.
    RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1 phase.
    FEBS Lett. , 372, 54-58 (1995)

  57. Rani, BR., Ubukata, M., and Osada, H.
    Reduction of arylcarbonyl using zinc dust in acetic acid.
    Bull. Chem. Soc. Jpn. , 68, 282-284 (1995)

  58. Ubukata, M., Koshino, H., Osada, H., and Isono, K.
    Absolute configuration of reveromycin A, an inhibitor of the signal transduction of epidermal growth factor.
    J. Chem. Soc., Chem. Commun. , 1994, 1877-1878 (1994)

  59. Osada, H., Kikuchi, K., Makishima, H., and Isono, K.
    Inhibitory action of epiderstatin on EGF-stimulated growth of mouse epidermal BALB/MK cells without direct effect on protein kinase activities.
    Oncol. Res. , 6, 11-17 (1994)

  60. Ubukata, M., Uzawa, J., Osada, H., and Isono, K.
    Respinomycins, A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation.
    J. Antibiot. , 46, 942-951 (1993)

  61. Ubukata, M., Osada, H., Kudo, T., and Isono, K.
    Respinomycins, A1, A2, B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities.
    J. Antibiot. , 46, 936-941 (1993)

  62. Suzuki, M., Itoh, T., Osada, H., Rubin, JS., Aaronson, SA., Suzuki, T., Koga, N., Saito, T., and Mitsui,Y.
    Spleen derived growth factor, SDGF-3, is identified as keratiocyte growth factor (KGF).
    FEBS Lett. , 328, 17-20 (1993)

  63. Koshino, H., Kobinata, K., Uzawa, J., Uramoto, M., Isono, K., and Osada, H.
    Structure of malolactomycin A and B, novel 40-membered macrolide antibiotics.
    Tetrahedron, 49, 8827-8831 (1993)

  64. Kobinata, K., Koshino, H., Kusakabe, H., Kobayashi, Y., Yamaguchi, I., Isono, K., and Osada, H.
    Isolation and characterization of a new antibiotic, malolactomycin.
    J. Antibiot. , 46, 1912-1915 (1993)

  65. Kobinata, K., Koshino, H., Kudo,T., Isono, K., and Osada, H.
    RK-397, a new oxo pentaene antibiotic.
    J. Antibiot. , 46, 1616-1618 (1993)

  66. Koshino, H., Kobinata, K., Isono, K., and Osada, H.
    Structure of RK-397, a new oxo pentaene antibiotic.
    J. Antibiot. , 46, 1619-1621 (1993)

  67. Koshino, H., Takahashi, H., Osada, H., and Isono, K.
    Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures.
    J. Antibiot. , 45, 1420-1427 (1992)

  68. Takahashi, H., Osada, H., Koshino, H., Kudo, T., Amano, S., Shimizu, S., Yoshihama, M., and Isono, K.
    Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties.
    J. Antibiot. , 45, 1409-1413 (1992)

  69. Takahashi, H., Osada, H., Koshino, H., Sasaki, M., Onose, R., Nakakoshi, M., Yoshihama, M., and Isono, K.
    Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.
    J. Antibiot. , 45, 1414-1419 (1992)

  70. Koshino, H., Osada, H., Amano, S., Onose, R., and Isono, K.
    A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).
    J. Antibiot. , 45, 1428-1432 (1992)

  71. Osada, H., Satake, M., Koshino, H., Onose, R., and Isono, K.
    A new indolocarbazole antibiotic, RK-286D.
    J. Antibiot. , 45, 278-279 (1992)

  72. Osada, H., Koshino, H., Kudo, T., Onose, R., and Isono, K.
    A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.
    J. Antibiot. , 45, 189-194 (1992)

  73. Koshino, H., Osada, H., and Isono, K.
    A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties, and structure.
    J. Antibiot. , 45, 195-198 (1992)

  74. Osada, H., Sasaki, M., Sonoda, T., and Isono, K.
    Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rouse sarcoma virus.
    Biosci. Biotechnol. Biochem. , 56, 1801-1806 (1992)

  75. Sonoda, T., Kobayashi, K., Ubukata, M., Osada, H., and Isono, K.
    Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus.
    J. Antibiot. , 45, 1963-1965 (1992)

  76. Osada, H., Koshino, H., Isono, K., Takahashi, H., and Kawanishi, G.
    Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor.
    J. Antibiot. , 44, 259-261 (1991)

  77. Sonoda, T., Osada, H., Uzawa, J., and Isono, K.
    Actiketal, a new member of the glutarimide antibiotics.
    J. Antibiot. , 44, 160-163 (1991)

  78. Osada, H., Yano, T., Koshino, H., and Isono, K.
    Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity.
    J. Antibiot. , 44, 1463-1466 (1991)

  79. Koshino, H., Osada, H., Yano, T., Uzawa, J., and Isono, K.
    The structure of enopeptins A and B, novel depsipeptide antibiotics.
    Tetrahedron Lett. , 32, 7707-7710 (1991)

  80. Kobinata, K., Sekido, S., Uramoto, M., Ubukata, M., Osada, H., Yamaguchi, I., and Isono, K.
    Isoxazole-4-carboxylic acid as a metabolite of Streptomyces sp. and its herbicidal activity.
    Agric. Biol. Chem. , 55, 1415-1416 (1991)

  81. Usui T, Yoshida M, Abe K, Osada H, Isono K, Beppu T.
    Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a.
    J Cell Biol, 115(5): 1275-1282 (1991) PMID: 1955475
  82. Ubukata, M., Tanaka, C., Osada, H., and Isono, K.
    Respinomycin A1, a new anthracycline antibiotic.
    J. Antibiot. , 44, 1274-1276 (1991)

  83. Magae, J., Osada, H., Fujiki, H., Saido, TC., Suzuki, K., Nagai, K., Yamasaki, M., and Isono, K.
    Morphological changes of human myeloid leukemia K-562 cells by a protein phosphatase inhibitor, tautomycin.
    Proc. Japan Acad. , 66(B), 209-212 (1990)

  84. Takahashi, H., Osada, H., Uramoto, M., and Isono, K.
    A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). II. Isolation, physico-chemical properties and structure.
    J. Antibiot. , 43, 168-173 (1990)

  85. Sonoda, T., Osada, H., Magae, J., and Isono, K.
    Epiderstatin and its related glutarimide antibiotics inhibited the cell growth induced by mitogen stimulation.
    Agric. Biol. Chem. , 54, 1259-1263 (1990)

  86. Osada, H., Takahashi, H., Tsunoda, K., Kusakabe, H., and Isono, K.
    A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity.
    J. Antibiot. , 43, 163-167 (1990)

  87. Osada, H., Uramoto, M., Uzawa, J., Kajikawa, K., and Isono, K.
    New pyrrolobenzodiazepine antibiotics, RK-1441 A and B. II. isolation and structure determination.
    Agric. Biol. Chem. , 54, 2883-2887 (1990)

  88. Osada, H., Ishinabe, K., Yano, T., Kajikawa, K., and Isono, K.
    New pyrrolobenzodiazepine antibiotics, RK-1441 A and B. I. biological properties.
    Agric. Biol. Chem. , 54, 2875-2881 (1990)

  89. Rubin, JS., Osada, H., Finch, PW., Taylor, WG., Rudikoff, S., and Aaronson, SA.
    Purification and characterization of a newly identified growth factor specific for epithelial cells.
    Proc. Natl. Acad. Sci. USA. , 86, 802-806 (1989)

  90. Sonoda, T., Osada, H., Uramoto, M., Uzawa, J., and Isono, K.
    Epiderstatin, a new inhibitor of the mitogenic activity of epidermal growth factor. II. Structure elucidation.
    J. Antibiot. , 42, 1607-1609 (1989)

  91. Osada, H., Sonoda, T., Kusakabe, H., and Isono, K.
    Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization.
    J. Antibiot. , 42, 1599-1606 (1989)

  92. Osada, H., Sonoda, T., Tsunoda, K., and Isono, K.
    A new biological role of sangivamycin; Inhibition of protein kinases.
    J. Antibiot. , 42, 102-106 (1989)

  93. Magae, J., Osada, H., Nagai, K., Yamasaki, M., and Isono, K.
    Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell free system.
    J. Antibiot. , 42, 1290-1293 (1989)

  94. Cheng, X-C., Kihara, T., Ying, X., Uramoto, M., Osada, H., Kusakabe, H., Wang, B-N., Kobayashi, Y., Ko, K., Yamaguchi, I., Shen, Y-C., and Isono, K.
    A new antibiotic, tautomycetin.
    J. Antibiot. , 42, 141-144 (1989)

  95. Magae, J., Watanabe, C., Osada, H., Cheng, X-C., and Isono, K.
    Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.
    J. Antibiot. , 41, 932-937 (1988)

  96. Osada, H., Magae, J., Watanabe, C., and Isono, K.
    Rapid screening method for inhibitors of protein kinase C.
    J. Antibiot. , 41, 925-931 (1988)

  97. Ubukata, M., Osada, H., Magae, J., and Isono, K.
    Synthesis and biological activity of aminoacyl analogs of ascamycin.
    Agric. Biol. Chem. , 52, 1117-1122 (1988)

  98. Osada, H., and Isono, K.
    Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase in mammalian cell membranes and susceptibility to ascamycin.
    J. Antibiot. , 39, 286-293 (1986) PubMed

  99. Osada, H., and Isono, K.
    Purification and characterization of ascamycin hydrolyzing aminopeptidase from Xanthomonas citri.
    Biochem. J. , 233, 459-463 (1986) PubMed

  100. Osada, H., and Isono, K.
    Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic.
    Antimicrob. Agents Chemother. , 27, 230-233 (1985) PubMed

  101. Osada, H., and Beppu, T.
    Lipopolysaccharide defective mutant of Escherichia coli with decreased sensitivity to colicin E2.
    Agric. Biol. Chem. , 49, 1813-1819 (1985)