Original Articles 2005

  1. Shoji, M., Uno, T., Kakeya, H., Onose, R., Shiina, I., Osada, H., and Hayashi, Y.
    Enantio- and diastereo-selective total synthesis of EI-1941-1, -2 and -3, inhibitors of interleukin-1alpha converting enzyme and biological properties of their derivatives.
    J. Org. Chem., 70, 9905-9915 (2005) PubMed

  2. Sudo, T., Kawai, K., Matsuzaki, H., and Osada, H.
    p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.
    Biochem. Biophys. Res. Commun., 337, 415-421 (2005) PubMed

  3. Hayashi, Y., Shoji, M., Mukaiyama, T., Gotoh, H., Yamaguchi, S., Nakata, M., Kakeya, H., and Osada, H.
    First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry.
    J. Org. Chem., 70, 5643-5654 (2005) PubMed

  4. Han, X-X., Cui, C-B., Gu, Q-Q., Zhu, W-M., Liu, H-B., Gu, J-Y., and Osada, H.
    ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007.
    Tetrahedron Lett., 46, 6137-6140 (2005)

  5. Mitsui, T., Miyake, Y., Kakeya, H., Hayashi, Y., Osada, H. and Kataoka, T.
    RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas liganddependent apoptosis in CTL-mediated cytotoxicity.
    Biosci. Biotechnol. Biochem., 69, 1923-1928 (2005) PubMed

  6. Nakazawa, J., Watanabe, N., Imoto, M., and Osada, H.
    Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus Type 1 Vpr in budding yeasts, S. cerevisiae.
    J. Gen. Appl. Microbiol., 51, 245-256 (2005) PubMed

  7. Muguruma, H., Yano, S., Kakiuchi, S., Uehara, H., Kawatani, M., Osada, H., and Sone, S.
    Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an anti-osteoclastic activity.
    Clin. Cancer Res., 11, 8822-8828 (2005) PubMed

  8. Watanabe, N., Arai, H., Iwasaki, J-I., Shiina, M., Ogata, K., Hunter, T., and Osada, H.
    Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.
    Proc. Natl. Acad. Sci., USA., 102, 11663-11668 (2005) PubMed

  9. Simizu, S., Takagi, S., Tamura, Y., and Osada, H.
    RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.
    Cancer Res., 65, 7455-7461 (2005) PubMed

  10. Kanoh, N., Honda, K., Simizu, S., Muroi, M., and Osada, H.
    Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.
    Angew. Chem. Int. Ed., 44, 3559-3562 (2005) PubMed

  11. Yamaguchi, J., Kakeya, H., Uno, T., Shoji, M., Osada, H., and Hayashi, Y.
    Determination by asymmetric total synthesis of the absolute configuration of Lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.
    Angew. Chem. Int. Ed., 44, 3110-3115 (2005) PubMed

  12. Teruya, T., Simizu, S., Kanoh, N., and Osada, H.
    Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.
    FEBS Lett., 579, 2463-2468 (2005) PubMed

  13. Shoji, M., Imai, H., Mukaida, M., Sakai, K., Kakeya, H., Osada, H., and Hayashi, Y.
    Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction.
    J. Org. Chem., 70, 79-91 (2005) PubMed

  14. Kakeya, H., Onose, R., Koshino, H., and Osada, H.
    Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
    Chem. Commun., 20, 2575-2577 (2005) PubMed

  15. Nagumo, Y., Kakeya, H., Shoji, M., Hayashi, Y., Domae, N., and Osada, H.
    Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.
    Biochem J., 387, 835-840 (2005) PubMed