Original Articles 2002

  1. Miyamoto, Y., Machida, K., Mizunuma, M., Emoto, Y., Sato, N., Miyahara, K., Hirata, D., Usui, T., Takahashi, H., Osada, H., and Miyakawa, T.
    Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as target of G1-specific inhibitor reveromycin A.
    J. Biol. Chem., 277, 28810-28814 (2002) PubMed

  2. Matsuyama, A., Shimazu, T., Sumida, Y., Saito, A., Yoshimatsu, Y., Seigneurin-Berny, D., Osada, H., Komatsu, Y., Nishino, N., Khochbin, S., Horinouchi, S., and Yoshida, M.
    In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
    EMBO J., 21, 6820-6831 (2002) PubMed

  3. Lee, MS., Oh, WK., Kim, BY., Ahn, SC., Kang, DO., Sohn, CB., Osada, H., and Ahn, JS.
    Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.
    Planta Med., 68, 1063-1065. (2002) PubMed

  4. Sirirath, S., Tanaka, J., Ohtani, N., Ichiba, T., Rachmat, R., Ueda, K., Usui, T., Osada, H., and Higa, T.
    Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.
    J. Nat. Prod., 65, 1820-1823 (2002) PubMed

  5. Sebahar, PR., Osada, H., Usui, T., and Williams, RM.
    Asymmetric, stereocontrolled total synthesis of (+) and (-)-spirotryprostatin B via a diastereoselective azomethine ylide [1, 3] - dipolar cycloaddition reaction.
    Tetrahedron, 58, 6311-6322 (2002)

  6. Shoji, M., Kishida, S., Takeda, M., Kakeya, H., Osada, H., and Hayashi, Y.
    A practical total synthesis of both enantiomers of epoxyquinols A and B.
    Tetrahedron Lett., 43, 9155-9158 (2002)

  7. Cui, C-B., Zhao, QC., Cai, B., Yao, XS., and Osada, H.
    Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius poir.
    J. Asian. Nat. Prod. Res., 4, 243-252 (2002)

  8. Kakeya H, Takahashi-Ando N, Kimura M, Onose R, Yamaguchi I, Osada H.: Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
    Biosci Biotechnol Biochem, 66(12): 2723-2726 (2002) PMID: 12596876 [ doi: 10.1271/bbb.66.2723 ]
  9. Shimizu, T., Usui, T., Machida, K., Furuya, K., Osada, H., and Nakata, T.
    Chemical modification of reveromycin A and its biological activities.
    Bioorg. Med. Chem. Lett., 12, 3363-3366 (2002) PubMed

  10. Tanaka, Y., Ishikawa, F., Osada, H., Imajoh-Ohmi, S., Uchida, T., and Kakiuchi, T.
    Reveromycin A inhibits antigen receptor-mediated antigen presentation by B lymphoma cells via its effect on intracellular trafficking of the antigen.
    J. Antibiot., 55, 904-913 (2002) PubMed

  11. Hayashi, Y., Shoji, M., Yamaguchi, J., Sato, K., Yamaguchi, S., Mukaiyama, T., Sakai, K., Asami, Y., Kakeya, H., and Osada, H.
    Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor.
    J. Am. Chem. Soc., 124, 12078-12079 (2002) PubMed

  12. Kakeya, H., Onose, R., Yoshida, A., Koshino, H., and Osada, H.
    Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity.
    J. Antibiot., 55, 829-831 (2002) PubMed

  13. Shoji, M., Yamaguchi, J., Kakeya, H., Osada, H., and Hayashi, Y.
    Total synthesis of (+)-epoxyquinols A and B.
    Angew. Chem. Int. Ed., 41, 3192-3194 (2002) PubMed

  14. Ueda, K., Usui, T., Nakayama, H., Ueki, M., Takio, K., Ubukata, M., and Osada, H.
    4-Isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.
    FEBS Lett., 525, 48-52 (2002) PubMed

  15. Machida, K., Hayashi, Y., and Osada, H.
    A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism.
    J. Biol. Chem., 277, 31243-31248 (2002) PubMed

  16. Asami, Y., Kakeya, H., Onose, R., Yoshida, A., Matsuzaki, H., and Osada, H.
    Azaspirene, a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by a fungi Neosartorya sp.
    Organic Lett., 4, 2845-2848 (2002) PubMed

  17. Takahashi-Ando N, Kimura M, Kakeya H, Osada H, Yamaguchi I.: A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.
    Biochem J, 365(Pt 1): 1-6 (2002) PMID: 11978180 [ doi: 10.1042/BJ20020450 ]
  18. Takanami-Ohnishi, Y., Amano, S., Kimura, S., Asada, S., Utani, A., Maruyama, M., Osada, H., Tsunoda, H., Irukayama-Tomobe, Y., Goto, K., Karin, M., Sudo, T., and Kasuya, Y.
    Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.
    J. Biol. Chem., 277, 37896-37903 (2002) PubMed

  19. Cui, CB., Zhao, QC., Cai, B., Yao, XS., and Osada, H.
    A new polyphenolic compound from Rubus aleaefolius and its inhibitory activity on mammalian cell cycle at G0/G1 phase.
    Chinese Chem. Lett., 13, 327-330 (2002)

  20. Kakeya, H., Onose, R., Koshino, H., Yoshida, A., Kobayashi, K., Kageyama, S., and Osada, H.
    Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity iolated from fungal metabolites.
    J. Am. Chem. Soc., 124, 3496-3497 (2002) PubMed

  21. Prasain, JK., Ueki, M., Stefanowicz, P., and Osada, H.
    Rapid screenin and identification of cytochalasins by electrospray tandem mass spectrometry.
    J. Mass. Spectrometry, 37, 283-291 (2002) PubMed

  22. Sudo, T., Yagasaki, Y., Hama, H., Watanabe, N., and Osada, H.
    Exip, a new alternative splicing variant of p38alpha, can induce an earlier onset of apoptosis in heLa cells.
    Biochem. Biophys. Res. Commun., 291, 838-843 (2002) PubMed