Original Articles 2018

  1. Motoyama T, Nogawa T, Hayashi T, Hirota H, Osada H.: Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae by disturbance of the two-component signal transduction system.
    Chembiochem, [Epub ahead of print] (2018) PMID: 30443971 [ doi: 10.1002/cbic.201800620 ]
  2. Son S, Hong YS, Futamura Y, Jang M, Lee JK, Heo KT, Ko SK, Lee JS, Takahashi S, Osada H, Jang JH, Ahn JS.: Catenulisporolides, glycosylated triene macrolides from the chemically underexploited actinomycete Catenulispora species.
    Org Lett, 20(22): 7234-7238 (2018) PMID: 30379079 [ doi: 10.1021/acs.orglett.8b03160 ]
  3. Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.: Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
    PLoS Comput Biol, 14(10): e1006532 (2018) PMID: 30376562 [ doi: 10.1371/journal.pcbi.1006532 ]
  4. Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.: Structures and synthesis of hitoyopodins: bioactive aromatic sesquiterpenoids produced by the mushroom Coprinopsis cinerea.
    Org Lett, 20(19): 6294-6297 (2018) PMID: 30234313 [ doi: 10.1021/acs.orglett.8b02788 ]
  5. Nakano T, Tanaka S, Ohtani M, Yamagami A, Takeno S, Hara N, Mori A, Nakano A, Hirose S, Himuro Y, Kobayashi M, Kushiro T, Demura T, Asami T, Osada H, Shinozaki K.: FPX is a novel chemical inducer that promotes callus formation and shoot regeneration in plants.
    Plant Cell Physiol, 59(8): 1555-1567 (2018) PMID: 30053249 [ doi: 10.1093/pcp/pcy139 ]
  6. Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.: Catalytic enantioselective synthesis of a pyrrolizidine-alkaloid-inspired compound collection with antiplasmodial activity.
    J Org Chem, 83(13): 7033–7041 (2018) PMID: 29460633 [ doi: 10.1021/acs.joc.7b03202 ]
  7. Kato N, Nogawa T, Takita R, Kinugasa K, Kanai M, Uchiyama M, Osada H, Takahashi S.: Control of the stereochemical course of [4+2] cycloaddition during trans-decalin formation by Fsa2-family enzymes.
    Angew Chem Int Ed Engl, 57(31): 9754-9758 (2018) PMID: 29972614 [ doi: 10.1002/anie.201805050 ]
  8. Jang JP, Han JM, Jung HJ, Osada H, Jang JH, Ahn JS.: Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs.
    J Microbiol Biotechnol, 28(8):1332-1338 (2018) PMID: 30301313 [ doi: 10.4014.jmb/1806.06046 ]
  9. Qi J, Cheng L, Sun Y, Hirata Y, Ushida N, Ma Z, Osada H, Nishikawa T, Xiang L.: Identification of an asexual reproduction inducer of phytopathogenic and toxigenic Fusarium.
    Angew Chem Int Ed Engl, 57(27): 8100-8104 (2018) PMID: 29729060 [ doi: 10.1002/anie.201803329 ]
  10. Maeda K, Ichikawa H, Nakajima Y, Motoyama T, Ohsato S, Kanamaru K, Kobayashi T, Nishiuchi T, Osada H, Kimura M.: Identification and characterization of small molecule compounds that modulate trichothecene production by Fusarium graminearum.
    ACS Chem Biol, 13(5): 1260-1269 (2018) PMID: 29565558 [ doi: 10.1021/acschembio.8b00044 ]
  11. Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.: Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.
    Bioorg Med Chem, 26(8): 1453-1461 (2018) PMID: 29170028 [ doi: 10.1016/j.bmc.2017.11.009 ]
  12. Jang JP, Hwang GJ, Kwon MC, Ryoo IJ, Jang M, Takahashi S, Ko SK, Osada H, Jang JH, Ahn JS.: Pentaminomycins A and B, hydroxyarginine-containing cyclic pentapeptides from Streptomyces sp. RK88-1441.
    J Nat Prod, 81(4): 806-810 (2018) PMID: 29513529 [ doi: 10.1021/acs.jnatprod.7b00882 ]
  13. Yamagami A, Saito C, Sakuta M, Shinozaki K, Osada H, Nakano A, Asami T, Nakano T.: Brassinosteroids regulate vacuolar morphology in root meristem cells of Arabidopsis thaliana.
    Plant Signal Behav, 13(4):e1417722 (2018) PMID: 29252095 [ doi: 10.1080/15592324.2017.1417722 ]
  14. Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.: MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action.
    Bioinformatics, 34(7): 1251-1252 (2018) PMID: 29206899 [ doi: 10.1093/bioinformatics/btx732 ]
  15. Kato N, Furutani S, Otaka J, Noguchi A, Kinugasa K, Kai K, Hayashi H, Ihara M, Takahashi S, Matsuda K, Osada H.: Biosynthesis and structure-activity relationship studies of okaramines that target insect glutamate-gated chloride channels.
    ACS Chem Biol, 13(3): 561-566 (2018) PMID: 29384650 [ doi: 10.1021/acschembio.7b00878 ]
  16. Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.: Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells.
    Cancer Med, 7(3): 883-893 (2018) PMID: 29380537 [ doi: 10.1002/cam4.1339 ]
  17. Takagi H, Nogawa T, Futamura Y, Takahashi S, Osada H.: Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44.
    J Antibiot, 71(4): 480-482 (2018) PMID: 29410517 [ doi: 10.1038/s41429-017-0020-0 ]
  18. Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.: Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.
    Chem Sci, 9(11): 3014-3022 (2018) PMID: 29732085 [ doi: 10.1039/c7sc05040b ]
  19. Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K.: Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.
    Sci Rep, 8(1): 2769 (2018) PMID: 29426822 [ doi: 10.1038/s41598-018-20987-w ]
  20. Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahashi S, Osada H.: Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.
    J Antibiot, 71, 123–128 (2018) PMID: 28901329 [ doi: 10.1038/ja.2017.103 ]