Original Articles 2004

  1. Yagasaki, Y., Sudo, T., and Osada, H.
    Exip, a splicing variant of p38alpha participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway.
    FEBS Lett., 575, 136-140 (2004) PubMed

  2. Usui, T., Kazami, S., Dohmae, N., Mashimo, Y., Kondo, H., Tsuda, M., Terasaki, A., Ohashi, K., Kobayashi, J., and Osada, H.
    Amphidinolide H, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.
    Chem. Biol., 11, 1269-1277 (2004) PubMed

  3. Sekine, M., Okada, K., Seio, K., Obata, T., Sasaki, T., Kakeya, H., and Osada, H.
    Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug.
    Bioorg. Med. Chem., 12, 6343-6349 (2004) PubMed

  4. Sekine, M., Okada, K., Seio, K., Kakeya, H., Osada, H., and Sasaki, T.
    Structure-activity relationship of phosmidosine importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity.
    Bioorg. Med. Chem., 12, 5193-5201 (2004) PubMed

  5. Nagumo, Y., Kakeya, H., Yamaguchi, J., Uno, T., Shoji, M., Hayashi, Y., and Osada, H.
    Structure-activity relationships of epolactaene derivatives structural requirements for inhibition of Hsp60 chaperone actitity.
    Bioorg. Med. Chem. Lett., 14, 4425-4429 (2004) PubMed

  6. Bae, E., Oh, H., Oh, W., Kim, M., Kim, B., Kim, B., Sohn, C., Osada, H., and Ahn, J.
    A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme.
    Planta Med., 70, 869-870 (2004) PubMed

  7. Tamura, Y., Simizu, S., and Osada, H.
    The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria.
    FEBS Lett., 569, 249-255 (2004) PubMed

  8. Kondoh, M., Suzuki, I., Sato, M., Nagashima, F., Simizu, S., Harada, M., Fujii, M., Osada, H., Asakawa, Y., and Watanabe, Y.
    Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway.
    J. Pharmacol. Exp. Ther., 311, 115-122 (2004) PubMed

  9. Simizu, S., Ishida, K., and Osada, H.
    Heparanase as a molecular target of cancer chemotherapy.
    Cancer Sci., 95, 553-558 (2004) PubMed

  10. Ishida, K., Simizu, S., Teruya, T., Wierzba, MK., and Osada, H.
    Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agent.
    Bioorg. Med. Chem. Lett., 14, 2505-2509 (2004) PubMed

  11. Simizu, S., Ishida, K., Wierzba, MK., and Osada, H.
    Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.
    J. Biol. Chem., 279, 2697-2703. (2004) PubMed

  12. Sekine, M., Okada, K., Seio, K., Kakeya, H., Osada, H., Obata, T., and Sasaki, T.
    Synthesis of chemically stabilized phosmidosine analogues and the structure-activity relationship of phosmidosine.
    J. Org. Chem., 69, 314-326 (2004) PubMed

  13. Ishida, K., Hirai, G., Murakami, K., Teruya, T., Simizu, S., Sodeoka, M., and Osada, H.
    Structure-based design of a selective heparanase inhibitor as an antimetastatic agent.
    Molec. Cancer Therapeutics, 3, 1069-1077 (2004) PubMed

  14. Usui, T., Watanabe, H., Nakayama, H., Tada, Y., Kanoh, N., Kondoh, M., Asao, T., Takio, K., Watanabe, H., Nishikawa, K., Kitahara, T., and Osada, H.
    The anti-cancer natural product pironetin selectively targets Lys352 of alpha-tubulin.
    Chem. Biol., 11, 799-806 (2004) PubMed

  15. Shoji, M., Imai, H., Shiina, I., Kakeya, H., Osada, H., and Hayashi, Y.
    Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones. Importance of the intermolecular hydrogen-bonding.
    J. Org. Chem., 69, 1548-1556 (2004) PubMed

  16. Ishida, K., Teruya, T., Simizu, S., and Osada, H.
    Exploitation of heparanase inhibitors from microbial metabolites using an efficient visual screening system.
    J. Antibiot., 57, 136-142 (2004) PubMed

  17. Mitsui, T., Miyake, Y., Kakeya, H., Osada, H., and Kataoka,T.
    ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity.
    J. Immunol., 172, 3428-3436 (2004) PubMed

  18. Ishida, K., Wierzba, MK., Teruya, T., Simizu, S., and Osada, H.
    Novel heparan sulfate mimetic compounds as antitumor agents.
    Chem. Biol., 11, 367-377 (2004) PubMed

  19. Asami, Y., Kakeya, H., Onose, R., Chang, Y-H., Toi, M., and Osada, H.
    RK-805, an endothelial-cell-growth Inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2.
    Tetrahedron, 60, 7085-7091 (2004)

  20. Watanabe, N., Arai, H., Nishihara, Y., Taniguch, M., Watanabe, N., Hunter, T., and Osada, H.
    M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF{beta}-TrCP.
    Proc. Natl. Acad. Sci., USA., 101, 4419-4424 (2004) PubMed

  21. Simizu, S., Tamura, Y., and Osada, H.
    Dephosphorylation of Bcl-2 by protein phasphatase 2A resulted in apoptosis-resistance.
    Cancer Sci., 95, 266-270 (2004) PubMed