Original Articles 2011

  1. Takayama H, Takahashi S, Moriya T, Osada H, Iwabuchi Y, Kanoh N.:
    Detection of cytochrome P450 substrates by using a small-molecule droplet array on an NADH-immobilized solid surface.
    Chembiochem, 12 (18): 2748-2752 (2011) PubMed [ doi: 10.1002/cbic.201100541 ]
  2. Kazami S, Usui T, Osada H.: Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins.
    Biosci Biotechnol Biochem, 75(9): 1853-1855 (2011) PMID: 21897009 [ doi: 10.1271/bbb.110334 ]
  3. Ishitsuka R, Saito T, Osada H, Ohno-Iwashita Y, Kobayashi T.: Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution.
    J Lipid Res. 52: 2084-2094 (2011) PubMed [ doi: 10.1194/jlr.D018184 ]
  4. Suzuki H, Takahashi S, Osada H, Yoshida K.: Improvement of transformation efficiency by strategic circumvention of restriction barriers in Streptomyces griseus.
    J Microbiol Biotechnol. 21: 675-678 (2011) PubMed
  5. Jang J.-H., Asami Y., Jang J.-P., Kim S.-O., Moon D.O., Shin K.-S., Hashizume D., Muroi M., Saito T., Oh H., Kim B.-Y., Osada H. and Ahn J.-S.: Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326.
    J Am Chem Soc. 133: 6865–6867 (2011) PubMed [ doi: 10.1021/ja1110688 ]
  6. Kawatani M., Takayama H., Muroi M., Kimura S., Maekawa T., and Osada H.:
    Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.
    Chem Biol. 18: 743-751 (2011) PubMed [ doi: 10.1016/j.chembiol.2011.03.012 ]
  7. Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y and Osada H.:
    Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
    Nat Chem Biol. 7: 461-468 (2011) PubMed [ doi: 10.1038/nchembio.583 ]
  8. Panthee S., Takahashi S., Takagi H., Nogawa T., Oowada E., Uramoto M., and Osada H.:
    Furaquinocins I and J: Novel polyketide isoprenoid hybrid compounds from Streptomyces sp. SN-593.
    J Antibiot. 64: 509-513 (2011) PubMed [ doi: 10.1038/ja.2011.41 ]
  9. Kato N., Tokuoka M., Shinohara Y., Kawatani M., Uramoto M., Seshime Y., Fujii I., Kitamoto K., Takahashi T., Koyama Y., and Osada H.:
    Genetic safeguard against mycotoxin cyclopiazonic acid production in Aspergillus oryzae.
    ChemBioChem 12: 1376-1382 (2011) PubMed [ doi: 10.1002/cbic.201000672 ]
  10. Ong E.B.B., Watanabe N., Saito A., Galil K.H.A.E., Koito A., Najimudin N., and Osada H.:
    Vipirinin, a coumarin-based HIV-1 Vpr Inhibitor, interacts with a hydrophobic region of Vpr.
    J Biol Chem 286: 14049-14056 (2011) PubMed [ doi: 10.1074/jbc.M110.185397 ]
  11. Khan M.M., Simizu S., Lai N.S., Kawatani M., Shimizu T., and Osada H.:
    Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.
    ACS Chem Biol, 6: 245-251, (2011). PubMed [ doi: 10.1021/cb100387r ]
  12. Minagawa S., Kondoh Y., Sueoka K., Osada H., and Nakamoto H.:
    Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity.
    Biochem J, 435: 237-246, (2011). PubMed [ doi: 10.1042/BJ20100743 ]
  13. Kato N., Suzuki H., Takagi H., Uramoto M., Takahashi S., and Osada H.:
    Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigatus.
    ChemBioChem, 12: 711-714, (2011). PubMed [ doi: 10.1002/cbic.201000562 ]
  14. Hirai G., Tsuchiya A., Koyama Y., Otani Y., Oonuma K., Dodo K., Simizu S., Osada H., and Sodeoka M.:
    Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure.
    ChemMedChem, 6: 617-622, (2011). PubMed [ doi: 10.1002/cmdc.201100107 ]