Original Articles 2020

  1. Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.: Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
    Environ Pollut, [Epub ahead of print] (2020) PMID: 32717636 [ doi: 10.1016/j.envpol.2020.115179 ]
  2. Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J.: Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis.
    Aging (Albany NY), [Epub ahead of print] (2020) PMID: 32699185 [ doi: 10.18632/aging.103521 ]
  3. Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.: A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
    Biosci Biotechnol Biochem, [Epub ahead of print] (2020) PMID: 32640867 [ doi: 10.1080/09168451.2020.1789445 ]
  4. Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M.: Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.
    ACS Chem Biol, [Epub ahead of print] (2020) PMID: 32584541 [ doi: 10.1021/acschembio.0c00381 ]
  5. Watanabe K, Bat-Erdene A, Tenshin H, Cui Q, Teramachi J, Hiasa M, Oda A, Harada T, Miki H, Sogabe K, Oura M, Sumitani R, Mitsui Y, Endo I, Tanaka E, Kawatani M, Osada H, Matsumoto T, Abe M.: Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.
    Haematologica, [Epub ahead of print] (2020) PMID: 32586903 [ doi: 10.3324/haematol.2019.244418 ]
  6. Yun CS, Nishimoto K, Motoyama T, Shimizu T, Hino T, Dohmae N, Nagano S, Osada H.: Unique features of the ketosynthase domain in a non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
    J Biol Chem, [Epub ahead of print] (2020) PMID: 32565425 [ doi: 10.1074/jbc.RA120.013105 ]
  7. Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.: β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.
    Sci Rep, 10(1): 10230 (2020) PMID: 32576869 [ doi: 10.1038/s41598-020-66974-y ]
  8. Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.: Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
    Sci Rep, 10(1): 8691 (2020) PMID: 32457324 [ doi: 10.1038/s41598-020-65614-9 ]
  9. Kato S, Motoyama T, Uramoto M, Nogawa T, Kamakura T, Osada H.: Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.
    J Antibiot, 73(7): 475–479 (2020) PMID: 32139880 [ doi: 10.1038/s41429-020-0295-4 ]
  10. Kato S, Motoyama T, Futamura Y, Uramoto M, Nogawa T, Hayashi T, Hirota H, Tanaka A, Takahashi-Ando N, Kamakura T, Osada H.: Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94.
    Biosci Biotechnol Biochem, 84(6): 1303-1307 (2020) PMID: 32043422 [ doi: 10.1080/09168451.2020.1725419 ]
  11. Tabuchi A, Fukushima-Sakuno E, Osaki-Oka K, Futamura Y, Motoyama T, Osada H, Ishikawa NK, Nagasawa E, Tokimoto K.: Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes.
    Biosci Biotechnol Biochem, 84(5): 876-886 (2020) PMID: 31942814 [ doi: 10.1080/09168451.2020.1714421 ]
  12. Minamoto C, Miyazawa K, Tabuchi M, Hirano M, Mizuno M, Yoshizako M, Torii Y, Asano Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.: Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice.
    Am J Orthod Dentofacial Orthop, 157(5): 680-689 (2020) PMID: 32354441 [ doi: 10.1016/j.ajodo.2019.04.037 ]
  13. Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang JH, Ahn JS.: CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells.
    J Microbiol Biotechnol, 30(1), 31-37 (2020) PMID: 31752054 [ doi: 10.4014/jmb.1908.08043 ]
  14. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N: Measurement of ATPase activity of valosin-containing protein/p97.
    Bio-protocol: , 10, e3516 (2020) [ doi: 10.21769/BioProtoc.3516 ]
  15. Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H: Identification of target protein for bio-active small molecule using photo-cross linked beads and MALDI-TOF mass spectrometry.
    Bio-protocol: , 10, e3517 (2020) [ doi: 10.21769/BioProtoc.3517 ]
  16. Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.: Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
    Cell Chem Biol, 27(2), 186-196.e4 (2020) PMID: 31813846 [ doi: 10.1016/j.chembiol.2019.11.010 ]