Original Articles 2019

  1. Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shinya K, Kimura H, Yoshida M, Murakami S, Kondo Y.: Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
    J Biochem, [Epub ahead of print] (2019) PMID: 30690451 [ doi: 10.1093/jb/mvz007 ]
  2. Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.: Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
    Bioconjug Chem, 30(5): 1395-1404 (2019) PMID: 30888797 [ doi: 10.1021/acs.bioconjchem.9b00154 ]
  3. Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.: A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
    FEBS Lett, 593(8): 763-776 (2019) PMID: 30874300 [ doi: 10.1002/1873-3468.13361 ]
  4. Panthee S, Takahashi S, Hayashi T, Shimizu T, Osada H.: β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.
    Sci Rep, 9(1): 5802 (2019) PMID: 30967594 [ doi: 10.1038/s41598-019-42268-w ]
  5. Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J.: 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense-induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signaling pathways.
    Mol Pharm, 16(4): 1423–1432 (2019) PMID: 30763105 [ doi: 10.1021/acs.molpharmaceut.8b00939 ]
  6. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.: A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
    J Biol Chem, 294(9): 2988-2996 (2019) PMID: 30610116 [ doi: 10.1074/jbc.RA118.004741 ]
  7. Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS.: Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.
    Exp Mol Med, 51(2): 10 (2019) PMID: 30755586 [ doi: 10.1038/s12276-018-0200-4 ]
  8. Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.: Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.
    Nat Protoc, 14(2): 415-440 (2019) PMID: 30635653 [ doi: 10.1038/s41596-018-0099-1 ]
  9. Motoyama T, Nogawa T, Hayashi T, Hirota H, Osada H.: Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae by disturbance of the two-component signal transduction system.
    Chembiochem, 20(5): 693-700 (2019) PMID: 30443971 [ doi: 10.1002/cbic.201800620 ]
  10. Nogawa T, Futamura Y, Okano A, Suto M, Nakamura J, Ishihara K, Osada H.: Construction of a potato fraction library for the investigation of functional secondary metabolites.
    Biosci Biotechnol Biochem, 83(1): 65-75 (2019) PMID: 30286702 [ doi: 10.1080/09168451.2018.1525273 ]
  11. Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.: Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.
    Biochim Biophys Acta, 1867(1): 28–37 (2019) PMID: 29883687 [ doi: 10.1016/j.bbapap.2018.06.001 ]