Original Articles 2018

  1. Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.: Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.
    Chem Sci, 9(11): 3014-3022 (2018) PMID: 29732085 [ doi: 10.1039/c7sc05040b ]
  2. Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.: Catalytic enantioselective synthesis of a pyrrolizidine-alkaloid-inspired compound collection with antiplasmodial activity.
    J Org Chem, [Epub ahead of print] (2018) PMID: 29460633 [ doi: 10.1021/acs.joc.7b03202 ]
  3. Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K.: Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.
    Sci Rep, 8(1): 2769 (2018) PMID: 29426822 [ doi: 10.1038/s41598-018-20987-w ]
  4. Kato N, Furutani S, Otaka J, Noguchi A, Kinugasa K, Kai K, Hayashi H, Ihara M, Takahashi S, Matsuda K, Osada H.: Biosynthesis and structure-activity relationship studies of okaramines that target insect glutamate-gated chloride channels.
    ACS Chem Biol, 13(3): 561-566 (2018) PMID: 29384650 [ doi: 10.1021/acschembio.7b00878 ]
  5. Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.: Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells.
    Cancer Med, 7(3): 883-893 (2018) PMID: 29380537 [ doi: 10.1002/cam4.1339 ]
  6. Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.: Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.
    Bioorg Med Chem, 26(8): 1453-1461 (2018) PMID: 29170028 [ doi: 10.1016/j.bmc.2017.11.009 ]
  7. Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahashi S, Osada H.: Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.
    J Antibiot, 71, 123–128 (2018) PMID: 28901329 [ doi: 10.1038/ja.2017.103 ]