Original Articles 2017

  1. Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahashi S, Osada H.: Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.
    J Antibiot, [Epub ahead of print] (2017) PMID: 28901329 [ doi: 10.1038/ja.2017.103 ]
  2. Enomoto R, Kurosawa A, Nikaido Y, Mashiko M, Saheki T, Nakajima N, Kuroiwa S, Otobe M, Ohsaki M, Tooyama K, Inoue Y, Kuwabara N, Kikuchi O, Kitamura T, Kojima I, Nakagawa Y, Saito T, Osada H, Futahashi M, Sezutsu H, Takeda S.: A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test.
    Eur J Pharmacol, [Epub ahead of print] (2017) PMID: 28823924 [ doi: 10.1016/j.ejphar.2017.08.017 ]
  3. Yun CS, Motoyama T, Osada H.: Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae.
    ACS Chem Biol, 12(9): 2270-2274 (2017) PMID: 28820236 [ doi: 10.1021/acschembio.7b00353 ]
  4. Otagiri M, Khalid A, Moriya S, Osada H, Takahashi S.: Novel squalene-producing thraustochytrids found in mangrove water.
    Biosci Biotechnol Biochem, [Epub ahead of print] (2017) PMID: 28795620 [ doi: 10.1080/09168451.2017.1359485 ]
  5. Yamagami A, Saito C, Nakazawa M, Fujioka S, Uemura T, Matsui M, Sakuta M, Shinozaki K, Osada H, Nakano A, Asami T, Nakano T.: Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation.
    Sci Rep, 7(1): 5739 (2017) PMID: 28720789 [ doi: 10.1038/s41598-017-06016-2 ]
  6. Amagai K, Ikeda H, Hashimoto J, Kozone I, Izumikawa M, Kudo F, Eguchi T, Nakamura T, Osada H, Takahashi S, Shin-Ya K.: Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.
    Sci Rep, 7(1): 3382 (2017) PMID: 28611443 [ doi: 10.1038/s41598-017-03308-5 ]
  7. Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.: Functional annotation of chemical libraries across diverse biological processes.
    Nat Chem Biol, 13(9): 982-993 (2017) PMID: 28759014 [ doi: 10.1038/nchembio.2436 ]
  8. Otaka J, Hashizume D, Masumoto Y, Muranaka A, Uchiyama M, Koshino H, Futamura Y, Osada H.: Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea.
    Org Lett, 19 (15), 4030–4033 (2017) PMID: 28726419 [ doi: 10.1021/acs.orglett.7b01784 ]
  9. Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KYJ.: Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.
    Chem Biol Drug Des, 89(6): 862-869 (2017) PMID: 27863017 [ doi: 10.1111/cbdd.12909 ]
  10. Maeda K, Nakajima Y, Motoyama T, Kondoh Y, Kawamura T, Kanamaru K, Ohsato S, Nishiuchi T, Yoshida M, Osada H, Kobayashi T, Kimura M.: Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein.
    Pestic Biochem Physiol, 138: 1-7 (2017) PMID: 28456298 [ doi: 10.1016/j.pestbp.2017.03.006 ]
  11. Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T.: Structure-activity relationships of terpendole E and its natural derivatives.
    ChemistrySelect, 2(4): 1533-1536 (2017) [ doi: 10.1002/slct.201602015 ]
  12. Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, Imoto M.: Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.
    Cancer Sci, 108(4): 772-784 (2017) PMID: 28107588 [ doi: 10.1111/cas.13172 ]
  13. Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H.: Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684.
    J Antibiot, 70(5): 705-707 (2017) PMID: 28096547 [ doi: 10.1038/ja.2016.167 ]
  14. Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H.: Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum.
    J Nat Prod, 80(1): 134-140 (2017) PMID: 28055207 [ doi: 10.1021/acs.jnatprod.6b00758 ]
  15. Noguchi T, Ishiba H, Honda K, Kondoh Y, Osada H, Ohno H, Fujii N, Oishi S.: Synthesis of Grb2 SH2 Domain Proteins for Mirror-Image Screening Systems.
    Bioconjug Chem, 28(2): 609-619 (2017) PMID: 28032751 [ doi: 10.1021/acs.bioconjchem.6b00692 ]
  16. Zhang L, Hashimoto T, Qin B, Hashimoto J, Kozone I, Kawahara T, Okada M, Awakawa T, Ito T, Asakawa Y, Ueki M, Takahashi S, Osada H, Wakimoto T, Ikeda H, Shin-Ya K, Abe I.: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
    Angew Chem Int Ed Engl, 56(7): 1740-1745 (2017) PMID: 28133950 [ doi: 10.1002/anie.201611371 ]
  17. Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H.: RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441.
    J Antibiot, 70(1): 102-104 (2017) PMID: 27270302 [ doi: 10.1038/ja.2016.65 ]
  18. Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M.: Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana.
    Plant Cell Physiol, 58 (1): 95-105 (2017) PMID: 28011868 [ doi: 10.1093/pcp/pcw181 ]
  19. Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H.: Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.
    J Antibiot, 70(2): 222-225 (2017) PMID: 27599762 [ doi: 10.1038/ja.2016.113 ]
  20. Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI.: Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.
    J Antibiot, 70(4): 429-434 (2017) PMID: 27507633 [ doi: 10.1038/ja.2016.99 ]