Reviews

Reviews and Proceedings

  1. Osada H.
    Trends in Bioprobe Research.
    Bioprobes (Ed. H. Osada), Springer, 1-10 (2017) [ doi: 10.1007/978-4-431-56529-1 ]

  2. Motoyama T, Osada H.: Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.
    Bioorg Med Chem Lett, 26(24): 5843-5850 (2016) PMID: 27865702 [ doi: 10.1016/j.bmcl.2016.11.013 ]
  3. Osada H.: Chemical and biological studies of reveromycin A.
    J Antibiot, 69(10): 723-730 (2016) PMID: 27270304 [ doi: 10.1038/ja.2016.57 ]
  4. Watanabe N, Osada H.: Small molecules that target phosphorylation dependent protein-protein interaction.
    Bioorg Med Chem, 24(15): 3246-3254 (2016) PMID: 27017542 [ doi: 10.1016/j.bmc.2016.03.023 ]
  5. Muroi M, Futamura Y, Osada H.: Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.
    Nat Prod Rep, 33(5): 621-625 (2016) PMID: 26996806 [ doi: 10.1039/c5np00106d ]

  6. Kondoh Y, Honda K, Osada H.: Construction and application of a photo-cross-linked chemical array.
    Methods Mol Biol, 1263, 29-41 (2015) PMID: 25618334 [ doi: 10.1007/978-1-4939-2269-7_3 ]

  7. Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.:
    NPD926, a small molecule inducer of reactive oxygen species, kills cancer cells via glutathione depletion.
    Eur J Cancer , 50 (Suppl.6): 14 (2014) [ doi: 10.1016/S0959-8049(14)70152-2 ]
  8. Glickman JF, Lundbäck T, Napper AD, Niles WD, Simeonov A, Weaver CD, Yin HH, Zaman GJ, Osada H.: Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility.
    Assay Drug Dev Technol, 12 (8): 443-451 (2014) PMID: 25383720 [ doi: 10.1089/adt.2014.1501 ]
  9. Hiroyuki Osada, Makoto Muroi, Yasumitsu Kondoh and Yushi Futamura: A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo-Cross-Linking Beads
    Concepts and Case Studies in Chemical Biology (Ed. Hervert Waldmann, Petra Janning), Wiley-VCH, 163-175 (2014)
  10. Kawatani M, Osada H.: Affinity-based target identification for bioactive small molecules.
    Med. Chem. Commun., 5, 277-287 (2014) [ doi: 10.1039/c3md00276d ]

  11. Wada A, Kato N, Ziegler S.: Joint knowledge and technology for systems chemical biology.
    Chembiochem, 14 (12): 1504-1506 (2013) PubMed [ doi: 10.1002/cbic.201300412 ]
  12. Nakamoto H, Osada H.: Molecular chaperones as drug targets.
    Curr Pharm Des, 19 (3): 307-308 (2013) PubMed
  13. Futamura Y, Muroi M, Osada H.: Target identification of small molecules based on chemical biology approaches.
    Mol Biosyst, 9(5): 897-914 (2013) PubMed [ doi: 10.1039/c2mb25468a ]
  14. Kondoh Y, Osada H.
    High-throughput screening identifies small molecule inhibitors of molecular chaperones.
    Curr Pharm Des, 19 (3): 473-492 (2013) PubMed

  15. Watanabe N, Ooi LC, Osada H.
    High-throughput screening to identify small molecule inhibitors of p27Kip1 ubiquitination,
    Eur. J. Cancer, 48 (Suppl.6): 84, (2012) [ doi: 10.1016/S0959-8049(12)72071-3 ]
  16. Watanabe N, Osada H.
    Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy.
    Curr Drug Targets, 13 (13): 1654-1658 (2012) PubMed
  17. Kato N, Takahashi S, Nogawa T, Saito T, Osada H.
    Construction of a microbial natural product library for chemical biology studies.
    Curr Opin Chem Biol.,16(1-2): 101-108 (2012) PubMed [ doi: 10.1016/j.cbpa.2012.02.016 ]
  18. Osada H, Muroi M, Yoshida M.
    The chemistry/biology interface.
    Bioorg Med Chem., 20, 1844-1845 (2012) PubMed [ 10.1016/j.bmc.2012.02.053 ]

  19. Wierzba K., Muroi M., and Osada H.
    Proteomics accelerating the identification of the target molecule of bioactive small molecules.
    Curr Opin Chem Biol, 15: 57-65, 2011PubMed [ doi: 10.1016/j.cbpa.2010.10.009 ]

  20. Osada H, Hertweck C.: Exploring the chemical space of microbial natural products.
    Curr Opin Chem Biol, 13 (2): 133-134 (2009) PubMed [ doi: 10.1016/j.cbpa.2009.03.017 ]
  21. Kawatani M, Osada H.: Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.
    Cancer Sci, 100 (11): 1999-2005 (2009) PubMed [ doi: 10.1111/j.1349-7006.2009.01294.x ]
  22. Osada, H.,
    Chemical biology based on small molecule-protein interaction. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 1-10 (2009)
  23. Kanoh, N., and Osada, H.,
    Recent developments and advances in chemical array. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 57-80 (2009).
  24. Usui, T., Saito, A., and Osada, H.,
    Data on small molecules and their target proteins. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 239-276 (2009).

  25. Kwon HJ, Lee CH, Osada H, Yoshida M. and Imoto M.
    Hot springs and cool natural products.
    Nat Chem Biol., 4, 444-446 (2008) PubMed

  26. Osada H.
    The Japanese society for chemical biology.
    ACS Chemi. Biol., 1, 8 (2006)
  27. Osada H, Hagiwara M, Toshima K. and Imoto M.
    The education system for chemical biology in Japanese universities.
    ACS Chem. Biol., 1, 492-494 (2006) PubMed

  28. Machida K. and Osada H.
    Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it determine whether cytochrome c release is dependent on permeability transition or not?
    Ann. NY. Acad. Sci., 1010, 182-185 (2003) PubMed
  29. Okada K, Taguchi H, Seio K, Kakeya H, Osada H, Sasaki T. and Sekine M.
    Synthesis and biological properties of stable phosmidosine analogs.
    Nucleic Acids Res. Suppl., 2003, 105-106 (2003) PubMed
  30. Osada H.
    Development and application of bioprobes for mammalian cell cycle analyses.
    Curr. Med. Chem., 10, 727-732 (2003) PubMed

  31. Sudo T, Maruyama M. and Osada H.
    Stress meets development in p38 MAP kinase.
    Molecular anatomy of cellular systems, 22, 3-11 (2002)

  32. Usui T, Nakazawa J. and Osada H.
    Studies on inhibitory mechanism of microtubule inhibitors.
    RIKEN Review, 41, 92-93 (2001)
  33. Sudo T, Maruyama M, Yagasaki Y. and Osada H.
    Over the stress responses:Functional analyses of p38alpha.
    RIKEN Review, 41, 64-66 (2001)
  34. Osada H.
    An overview on the diversity of actinomycete metabolites.
    Actinomycetol., 15, 11-14 (2001)

  35. Osada H.
    Differentiation.
    Bioprobes (Ed. H. Osada), Springer, 43-65 (2000)
  36. Usui T. and Osada H.
    Bioprobes at a glance.
    Bioprobes (Ed. H. Osada), Springer, 126-305 (2000)
  37. Osada H.
    Trends in bioprobe research.
    Bioprobes (Ed. H. Osada), Springer, 1-14 (2000)

  38. Kakeya H, Onose O. and Osada H.
    Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins,during anticancer drug-induced apoptosis.
    Ann. NY. Acad. Sci., 886, 273-275 (1999) PubMed

  39. Osada H.
    Actinomycetes, how fascinating microorganisms.
    Actinomycetol., 12, 85-88 (1998)
  40. Kagami S, Kimura K, Ikeda Y, Takahashi H, Kusakabe H, Osada H, Isono K. and Yoshihama M.
    New types of liposidomycins which inhibit bacterial peptidoglycan synthesis produced by Streptomyces.
    Actinomycetol., 12, 110-119 (1998)
  41. Osada H.
    Bioprobes for investigating mammalian cell cycle control.
    J. Antibiot., 51, 973-981 (1998) PubMed
  42. Kakeya H. and Osada H.
    Induction of neurite outgrowth by epolactaene derivatives, 3-substituted 3-pyrrolin-2-ones.
    RIKEN Review , 18, 35-36 (1998)
  43. Osada H.
    Discovery and mechanism of action of nonpeptide neuritogenic compounds.
    Drugs of the Future , 23, 395-399 (1998)

  44. Osada H.
    Inhibitors of eukaryotic cell cycle from microbial metabolites.
    Biotechnology (Moscow) , 7-8, 205-209 (1995)
  45. Osada H.
    Fascinating bioactive compounds from actinomycetes.
    Actinomycetol., 9, 254-262 (1995)

  46. Lami N. and Osada H.
    Screening of biologically active secondary metabolites from Zairian (Africa) microorganisms.
    RIKEN Review, 3, 15-16 (1993)
  47. Osada H, Hanaoka F. and Isono K.
    Inhibitors of eukaryotic cell cycle from microbial metabolites.
    J. Cell. Biochem. suppl., 17A, 296 (1993)
  48. Osada H. and Isono K.
    Microbial secondary metabolites which regulate mammalian cell growth.
    In: C. Nash (ed.), Developments in Industrial Microbiology Series, Vol. 32, pp. 237-245. Dubuque: Wm. C. Brown Publishers (1993).

  49. Osada H, Hanaoka F. and Isono K.
    Effects of microbial inhibitors of protein kinases and phosphatases on the cell cycle progression of mouse tsFT210 cells.
    Second joint meeting of the AACR/JCA (Molecular oncology as a basis for new strategies in cancer therapy), Honolulu (1992)

  50. Osada H. and Isono K.
    Microbial secondary metabolites regulating mam malian cell growth.
    2nd International conference on the biotechnology of microbial products. (1990)

  51. Ubukata M, X.C. Cheng, Osada H, Magae J, Yamasaki M. and Isono K.
    Tautomycin, a new antibiotic which regulates eukaryotic cell growth.
    29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
  52. Osada H, Sonoda T and Isono K.
    Epiderstatin, a new antibiotic, which inhibits the mitogenic activity induced by epidermal growth factor.
    29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
  53. Osada H, Magae J, Tsunoda K, Watanabe C. and Isono K.
    Rapid screening method for activators/inhibitors of protein kinase C.
    Trends in Actinomycetology in Japan, Actinomycetologica Forum, 33-35 (1989)

  54. Ubukata M, Osada H. and Isono K.
    Synthesis and biological activity of nucleoside antibiotics, ascamycin and amino acid analogs.
    Nucleic Acids Res. Symp. Ser., 16, 81-83 (1985) PubMed

  55. Isono K, Uramoto M, Osada H, Ubukata M, Kusakabe H, Koyama T, Miyata N, Sethi SK. and McCloskey JA.
    Structure and biological activity of ascamycin, a new nucleoside antibiotic.
    Nucleic Acids Res. Symp. Ser., 15, 65- 67 (1984) PubMed