Books and Reviews

  1. Motoyama T, Yun CS, Osada H.: Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae.
    J Ind Microbiol Biotechnol, [Epub ahead of print] (2021) PMID: 34379774 [ doi: 10.1093/jimb/kuab058 ]
  2. Muroi M, Osada H.: Proteomics-based target identification of natural products affecting cancer metabolism.
    J Antibiot, [Epub ahead of print] (2021) PMID: 34282314 [ doi: 10.1038/s41429-021-00437-y ]

  3. Lopez JAV and Osada H.
    Fraction libraries and genetics as tools for natural product research: focus on decalin-containing compounds. In: Liu HB and Begley TP (eds.) Comprehensive natural products III: chemistry and biology. vol. 7, pp. 375-409, Elsevier, (2020) [ doi: 10.1016/B978-0-12-409547-2.14658-X]
  4. Watanabe N and Osada H.
    Small molecule inhibitors of E3 ubiquitin ligases In: Roy S. and Fu H (eds.) Protein–protein interaction regulators. Drug discovery series No. 78 pp. 109-123, Royal society of chemistry, (2020) [ doi: 10.1039/9781788016544]

  5. Osada H.
    Discovery and applications of nucleoside antibiotics beyond polyoxin.
    J Antibiot, 72, 853–854 (2019) PMID: 31554959 [ doi: 10.1038/s41429-019-0237-1 ]
  6. Muroi M and Osada H.
    Proteomic profiling for target identification of biologically active small molecules using 2D DIGE
    Systems Chemical Biology (Ziegler S. and Waldmann H. eds.): Methods and Protocols, Methods in Molecular Biology, 1888, 127-139 (2019) PMID: 30519944 [ doi: 10.1007/978-1-4939-8891-4_7 ]

  7. Watanabe N.
    Encyclopedia of signaling molecules, 2nd edition, 5986-5991 (2018) [ doi: 10.1007/978-3-319-67199-4_101526 ]
  8. Osada H.
    Trends in bioprobe research.
    Bioprobes (Ed. H. Osada), Springer, 1-10 (2017) [ doi: 10.1007/978-4-431-56529-1_1 ]
  9. Watanabe N, Osada H.
    Cell proliferation and differentiation.
    Bioprobes (Ed. H. Osada), Springer, 11-35 (2017) [ doi: 10.1007/978-4-431-56529-1_2 ]

  10. Motoyama T, Osada H.: Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.
    Bioorg Med Chem Lett, 26(24): 5843-5850 (2016) PMID: 27865702 [ doi: 10.1016/j.bmcl.2016.11.013 ]
  11. Osada H.: Chemical and biological studies of reveromycin A.
    J Antibiot, 69(10): 723-730 (2016) PMID: 27270304 [ doi: 10.1038/ja.2016.57 ]
  12. Watanabe N, Osada H.: Small molecules that target phosphorylation dependent protein-protein interaction.
    Bioorg Med Chem, 24(15): 3246-3254 (2016) PMID: 27017542 [ doi: 10.1016/j.bmc.2016.03.023 ]
  13. Muroi M, Futamura Y, Osada H.: Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.
    Nat Prod Rep, 33(5): 621-625 (2016) PMID: 26996806 [ doi: 10.1039/c5np00106d ]

  14. Kondoh Y, Honda K, Osada H.: Construction and application of a photo-cross-linked chemical array.
    Methods Mol Biol, 1263, 29-41 (2015) PMID: 25618334 [ doi: 10.1007/978-1-4939-2269-7_3 ]

  15. Glickman JF, Lundbäck T, Napper AD, Niles WD, Simeonov A, Weaver CD, Yin HH, Zaman GJ, Osada H.: Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility.
    Assay Drug Dev Technol, 12 (8): 443-451 (2014) PMID: 25383720 [ doi: 10.1089/adt.2014.1501 ]
  16. Osada H, Muroi M, Kondoh Y. and Futamura Y.: A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo-Cross-Linking Beads
    Concepts and Case Studies in Chemical Biology (Ed. Waldmann H and Janning P), Wiley-VCH, 163-175 (2014) [ doi: 10.1002/9783527687503.ch11 ]
  17. Kawatani M, Osada H.: Affinity-based target identification for bioactive small molecules.
    Med. Chem. Commun., 5, 277-287 (2014) [ doi: 10.1039/c3md00276d ]

  18. Wada A, Kato N, Ziegler S.: Joint knowledge and technology for systems chemical biology.
    Chembiochem, 14 (12): 1504-1506 (2013) PubMed [ doi: 10.1002/cbic.201300412 ]
  19. Nakamoto H, Osada H.: Molecular chaperones as drug targets.
    Curr Pharm Des, 19 (3): 307-308 (2013) PubMed [ doi: 10.2174/138161213804143671 ]
  20. Futamura Y, Muroi M, Osada H.: Target identification of small molecules based on chemical biology approaches.
    Mol Biosyst, 9(5): 897-914 (2013) PubMed [ doi: 10.1039/c2mb25468a ]
  21. Kondoh Y, Osada H.
    High-throughput screening identifies small molecule inhibitors of molecular chaperones.
    Curr Pharm Des, 19 (3): 473-492 (2013) PubMed [ doi: 10.2174 /138161213804143743 ]

  22. Watanabe N, Osada H.
    Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy.
    Curr Drug Targets, 13 (13): 1654-1658 (2012) PubMed [ doi: 10.2174/138945012803530035 ]
  23. Kato N, Takahashi S, Nogawa T, Saito T, Osada H.
    Construction of a microbial natural product library for chemical biology studies.
    Curr Opin Chem Biol.,16(1-2): 101-108 (2012) PubMed [ doi: 10.1016/j.cbpa.2012.02.016 ]
  24. Osada H, Muroi M, Yoshida M.
    The chemistry/biology interface.
    Bioorg Med Chem., 20, 1844-1845 (2012) PubMed [ 10.1016/j.bmc.2012.02.053 ]

  25. Wierzba K., Muroi M., and Osada H.
    Proteomics accelerating the identification of the target molecule of bioactive small molecules.
    Curr Opin Chem Biol, 15: 57-65, (2011)PubMed [ doi: 10.1016/j.cbpa.2010.10.009 ]

  26. Miyazaki, I., Simizu, S., and Osada, H.
    The application of the chemical array for biological study.
    Methods Molec Biol., 669, 95-107, (2010) PubMed [ doi: 10.1007/978-1-60761-845-4_8 ]

  27. Osada H, Hertweck C.: Exploring the chemical space of microbial natural products.
    Curr Opin Chem Biol, 13 (2): 133-134 (2009) PubMed [ doi: 10.1016/j.cbpa.2009.03.017 ]
  28. Kawatani M, Osada H.: Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.
    Cancer Sci, 100 (11): 1999-2005 (2009) PubMed [ doi: 10.1111/j.1349-7006.2009.01294.x ]
  29. Osada, H.,
    Chemical biology based on small molecule-protein interaction. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 1-10 (2009) [ doi: 10.1002/9780470495018.ch4 ]
  30. Kanoh, N., and Osada, H.,
    Recent developments and advances in chemical array. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 57-80 (2009). [ doi: 10.1002/9780470495018.ch4 ]
  31. Usui, T., Saito, A., and Osada, H.,
    Data on small molecules and their target proteins. Protein targeting with small molecules;
    Chemical biology techniques and applications (Ed Osada H.), 239-276 (2009). [ doi: 10.1002/9780470495018.ch4 ]

  32. Kwon HJ, Lee CH, Osada H, Yoshida M, Imoto M.
    Hot springs and cool natural products.
    Nat Chem Biol, 4(8): 444-446 (2008) PMID: 18641618 [ doi: 10.1038/nchembio0808-444 ]

  33. Osada H.
    The Japanese society for chemical biology.
    ACS Chemi. Biol., 1, 8 (2006) [ doi: 10.1021/cb0600039 ]
  34. Osada H, Hagiwara M, Toshima K, Imoto M.: The education system for chemical biology in Japanese universities.
    ACS Chem Biol, 1(8): 492-494 (2006) PMID: 17168534 [ doi: 10.1021/cb6003614 ]

  35. Simizu S, Ishida K, Osada H.: Heparanase as a molecular target of cancer chemotherapy.
    Cancer Sci, 95(7): 553-558 (2004) PMID: 15245589 [ doi: 10.1111/j.1349-7006.2004.tb02485.x ]

  36. Machida K. and Osada H.
    Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it determine whether cytochrome c release is dependent on permeability transition or not?
    Ann. NY. Acad. Sci., 1010, 182-185 (2003) PubMed
  37. Okada K, Taguchi H, Seio K, Kakeya H, Osada H, Sasaki T. and Sekine M.
    Synthesis and biological properties of stable phosmidosine analogs.
    Nucleic Acids Res. Suppl., 2003, 105-106 (2003) PubMed
  38. Osada H.
    Development and application of bioprobes for mammalian cell cycle analyses.
    Curr. Med. Chem., 10, 727-732 (2003) PubMed

  39. Sudo T, Maruyama M. and Osada H.
    Stress meets development in p38 MAP kinase.
    Molecular anatomy of cellular systems, 22, 3-11 (2002)

  40. Usui T, Nakazawa J. and Osada H.
    Studies on inhibitory mechanism of microtubule inhibitors.
    RIKEN Review, 41, 92-93 (2001)
  41. Sudo T, Maruyama M, Yagasaki Y. and Osada H.
    Over the stress responses:Functional analyses of p38alpha.
    RIKEN Review, 41, 64-66 (2001)
  42. Osada H.
    An overview on the diversity of actinomycete metabolites.
    Actinomycetol., 15, 11-14 (2001)

  43. Osada H.
    Bioprobes (Ed. H. Osada), Springer, 43-65 (2000)
  44. Usui T. and Osada H.
    Bioprobes at a glance.
    Bioprobes (Ed. H. Osada), Springer, 126-305 (2000)
  45. Osada H.
    Trends in bioprobe research.
    Bioprobes (Ed. H. Osada), Springer, 1-14 (2000)

  46. Kakeya H, Onose O. and Osada H.
    Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins,during anticancer drug-induced apoptosis.
    Ann. NY. Acad. Sci., 886, 273-275 (1999) PubMed

  47. Osada H.
    Actinomycetes, how fascinating microorganisms.
    Actinomycetol., 12, 85-88 (1998)
  48. Kagami S, Kimura K, Ikeda Y, Takahashi H, Kusakabe H, Osada H, Isono K. and Yoshihama M.
    New types of liposidomycins which inhibit bacterial peptidoglycan synthesis produced by Streptomyces.
    Actinomycetol., 12, 110-119 (1998)
  49. Osada H.
    Bioprobes for investigating mammalian cell cycle control.
    J. Antibiot., 51, 973-981 (1998) PubMed
  50. Kakeya H. and Osada H.
    Induction of neurite outgrowth by epolactaene derivatives, 3-substituted 3-pyrrolin-2-ones.
    RIKEN Review , 18, 35-36 (1998)
  51. Osada H.
    Discovery and mechanism of action of nonpeptide neuritogenic compounds.
    Drugs of the Future , 23, 395-399 (1998)

  52. Osada H.
    Inhibitors of eukaryotic cell cycle from microbial metabolites.
    Biotechnology (Moscow) , 7-8, 205-209 (1995)
  53. Osada H.
    Fascinating bioactive compounds from actinomycetes.
    Actinomycetol., 9, 254-262 (1995)

  54. Lami N. and Osada H.
    Screening of biologically active secondary metabolites from Zairian (Africa) microorganisms.
    RIKEN Review, 3, 15-16 (1993)
  55. Osada H, Hanaoka F. and Isono K.
    Inhibitors of eukaryotic cell cycle from microbial metabolites.
    J. Cell. Biochem. suppl., 17A, 296 (1993)
  56. Osada H. and Isono K.
    Microbial secondary metabolites which regulate mammalian cell growth.
    In: C. Nash (ed.), Developments in Industrial Microbiology Series, Vol. 32, pp. 237-245. Dubuque: Wm. C. Brown Publishers (1993).

  57. Osada H, Hanaoka F. and Isono K.
    Effects of microbial inhibitors of protein kinases and phosphatases on the cell cycle progression of mouse tsFT210 cells.
    Second joint meeting of the AACR/JCA (Molecular oncology as a basis for new strategies in cancer therapy), Honolulu (1992)

  58. Osada H. and Isono K.
    Microbial secondary metabolites regulating mam malian cell growth.
    2nd International conference on the biotechnology of microbial products. (1990)

  59. Ubukata M, X.C. Cheng, Osada H, Magae J, Yamasaki M. and Isono K.
    Tautomycin, a new antibiotic which regulates eukaryotic cell growth.
    29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
  60. Osada H, Sonoda T and Isono K.
    Epiderstatin, a new antibiotic, which inhibits the mitogenic activity induced by epidermal growth factor.
    29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
  61. Osada H, Magae J, Tsunoda K, Watanabe C. and Isono K.
    Rapid screening method for activators/inhibitors of protein kinase C.
    Trends in Actinomycetology in Japan, Actinomycetologica Forum, 33-35 (1989)

  62. Ubukata M, Osada H. and Isono K.
    Synthesis and biological activity of nucleoside antibiotics, ascamycin and amino acid analogs.
    Nucleic Acids Res. Symp. Ser., 16, 81-83 (1985) PubMed

  63. Isono K, Uramoto M, Osada H, Ubukata M, Kusakabe H, Koyama T, Miyata N, Sethi SK. and McCloskey JA.
    Structure and biological activity of ascamycin, a new nucleoside antibiotic.
    Nucleic Acids Res. Symp. Ser., 15, 65- 67 (1984) PubMed