New Natural Compounds purified in RIKEN (Antibiotics Lab and Chemical Biology Research Group)

Please click to show detail information on additional window.

* : re-discovered compounds as new bioactive roles other than previously reported.

 Compound nameBiological activityProducing organismYear reportedDetails
A acetophthalidin cell cycle inhibition Aspergillus sp. 1996
actiketal mitogen Streptomyces pulberaceus subsp. epiderstagenes 1991
albopeptin B antimicrobial Streptomyces albofaciens 1986, 92
ascamycin antibacterial Streptomyces sp. 1984
azaspirene antiangiogenesis Neosartorya sp. 2002
B benzyl-methylcoumarin p38MAPK inhibitors (Chemically synthesized) 2009
C cationomycin A - D antimicrobial Actinomadura azurea 1981-83
curvularol cytotoxic Curvularia sp. 2001
cyclotryprostatin A - D tubulin assemble inhibition Aspergillus fumigatus 1995
cytotrienin A, B apoptosis-inducing Streptomyces sp. 1997
cytovaricin cytostatic Streptomyces sp. 1981
cytoxazone cytokine modulator Streptomyces sp. 1998
D dephospho-phoslactomycin B differentiation inducer, enhancer of differentiation potential of all-trans retinoic acid. Streptomyces sp. 2009
E ECH * Fas-mediated apoptosis inhitibitor uncharacterized fungus 2003
enamidonin flat reversion activity of v-src transformed cells Streptomyces sp. 1995
enopeptin A, B anti-bacteriophage activity Streptomyces sp. RK-1051 1991
epiderstatin anti-mitogenic activity Streptomyces pulveraceus subsp. epiderstagenes 1989
epolactaene induction of neurite outgrowth Penicillium sp. 1995
epoxyquinol A, B angiogenic inhibitor uncharacterized fungus 2002
epoxytwinol A angiogenic inhibitor uncharacterized fungus 2005
F furaquinocin I, J (no cytotoxic activity) Streptomyces reveromyceticus SN-593 2011
G guanine 7-N-oxide antitumor Streptomyces sp. 1985
H hitoyol A, B weak anti-malarial activity Coprinopsis cinerea 2017
I indole-carbaldehyde (no biological activity reported) Streptomyces sp. SN-593 2010
iso-avenaciolide * phosphatase inhibitor Aspergillus sp. 2002
isoxazole 4-carboxylate herbicidal Streptomyces sp. 1991
J juniferdin Protein disulfide isomerase inhibitor Ferula junipernia 2011
L linearolide A, B weak cytotoxicity Streptomyces sp. RK95-74 2013
lipopeptin A - C antimicrobial Streptomyces sp. 1980
liposidomycin B, C antibacterical, inhibition of peptideglycan synthesis Streptomyces griseosporeus 1988-89
lucilactaene cell cycle inhibition Fusarium sp. 2001
M malolactomycin A antifungal Streptomyces sp. 83-634 1993
methyl gerfelin glyoxalase I inhibitor Beauveria felina 2008, 2013
N neopeptin A - C inhibition of fungal cell wall synthesis Streptomyces sp. 1986
NPD926 Glutathione depletion (Chemically synthesized) 2014
NPD6689 tubulin inhibitor (Chemically synthesized) 2012
O opantimycin A cytotoxicity and antimalarial activity Streptomyces sp. RK88-1355 2016
P phoslactomycin A - F phosphazomycin C1, C2 inhibitor of protein phosphatase 2A Streptomyces sp. 1985
phosmidosine antifungal Streptomyces sp. RK-16 1991
phosphatoquinone A, B inhibitor of protein tyrosine phosphatase Streptomyces sp. 1999
pironetin * tubulin disassembler Streptomyces sp. 1999
polyoxin A - M inhibition on fungal cell-wall synthesis Streptomyces cacaoi ver. asoensis 1968-72
protuboxepin A microtubule-stabilizing agent Aspergillus sp. 2011
purpurogallin * inhibitor of Plk1 Polo Box Domain-dependent binding nutgall 2009
pyrrolizilactone proteasome inhibitor an uncharacterized fungus 2013
Q questiomycin A, B antimicrobial Streptomyces sp. 1965
R respinomycin A - D induction of cell differentiation Streptomyces xanthocidicus 1991-93
reveromycin A - D antifungal, cytotoxic Streptomyces sp. SN593 1990-92
reveromycin T 1-methyl ester and 1-ethyl ester cytotoxicity against mammarial cancer cells Streptomyces reveromyceticus SN-593 2013
RK-286C, D inhibitor of protein kinase C Streptomyces sp. RK-286 1990
RK-397 antifungal Streptomyces violaceusnigar 1993
RK-682 * phosphatase inhibitor Streptomyces sp. 1995
RK-805 inhibitor of methionine aminopeptidase 2 Neosartorya sp. 2004
RK-1009 --- Streptomyces sp. 1998
RK-1355A, B cytotoxicity, antimicrobial Streptomyces sp. RK88-1355 2014
RK-1409A, B inhibitor of protein kinase C Streptomyces platensis subsp. malvinus RK-1409 1992
RK-1441A, B antibacteriophage Streptomyces sp. 1990
RK-95113 antiogenesis inhibitor Aspergillus fumigatus 2006
RS-22A - C antimicrobial Streptomyces violaceusnigar 1995
S sangivamycin * inhibitor of protein kinase C Streptomyces sp. 1989
sparoxomycin A1, A2 flat reversion activity of v-src transformed cells Streptomyces sparsogenes 1996
spirotoamide A, B (no antibacterial, antifungal, and cytotoxic activities) Streptomyces griseochromogenes JC82-1223 2012
stevastelin * Phosphatase inhibitor Aspergillus sp. 1997
T tautomycetin inhibition of protein phosphatase Streptomyces sp. 1989
tautomycin inhibition of protein phosphatase Streptomyces sp. 1987
terpendole E *, H, C, I cell cycle inhibition, inhibition of kinesin Eg5 Albophoma yamashiensis 2003
terpeptin cell cycle inhibition Aspergillus terreus 1997
TPh A inhibitor of pirin (Chemically synthesized) 2010
trichostatin RK -- Streptomyces sp. RK98-A74 2001
tryprostatin A, B
demethoxyfumitremorgin C
spirotryprostatin B
tubulin assemble inhibition Aspergillus fumigatus 1995
U unantimycin A cytotoxicity and antimalarial activity Streptomyces sp. RK88-1355 2016
V verticilactam no antibacterial, antifungal and cytotoxic activities Streptomyces spiroverticillatus JC-8444 2010
vipirinin HIV Vpr inhibitor (Chemically synthesized) 2011
W wakodecaline A, B moderate antimalarial activity Pyrenochaetopsis sp. RK10-F058 2017
X xanthohumol * valosin-containing protein inhibitor Humulus lupulus 2012
xanthostatin antibacterial Streptomyces sp. 1987