ケミカルバイオロジー研究グループ(終了)

Malolactomycin A

Structure
NPEdia Malolactomycin A
Producing organism
Streptomyces sp. 83-634 (Isolated in Okinawa, Japan)
Biological activity
antifungal activity
Abstract
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References
isolation and structural determination
  • Kobinata K, Koshino H, Kusakabe H, Kobayashi Y, Yamaguchi I, Isono K, Osada H.: Isolation and characterization of a new antibiotic, malolactomycin A.
    J Antibiot, 46(12): 1912-1915 (1993) PMID: 8294254
  • related compounds
  • Tanaka Y, Yoshida H, Enomoto Y, Shiomi K, Shinose M, Takahashi Y, Liu JR, Omura S.: Malolactomycins C and D, new 40-membered macrolides active against Botrytis.
    J Antibiot, 50(3): 194-200 (1997) PMID: 9127189
  • Futamura M, Kamiya S, Tsukamoto M, Hirano A, Monden Y, Arakawa H, Nishimura S.: Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells.
    Oncogene, 20(46): 6724-6730 (2001) PMID: 11709707 [ doi: 10.1038/sj.onc.1204878 ]
  • Additional information