ケミカルバイオロジー研究グループ(終了)

Phoslactomycin A, B, C, D, E, F Phosphazomycin C1, C2

Structure
Phoslactomycin
A: NPEdia
B: NPEdia
C: NPEdia
D: NPEdia
E: NPEdia
F: NPEdia
Phosphazomycin
C1: NPEdia
C2: NPEdia
Phoslactomycin
Producing organism
Streptomyces sp.
Biological activity
protein phosphatase 2A inhibitor
Abstract
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References
isolation and structural determination
  • Uramoto M, Shen YC, Takizawa N, Kusakabe H, Isono K.: A new antifungal antibiotic, phosphazomycin A.
    J Antibiot, 38(5): 665-668 (1985) PMID: 3839498
  • Tomiya T, Uramoto M, Isono K.: Isolation and structure of phosphazomycin C.
    J Antibiot, 43(1): 118-121 (1990) PMID: 2307624
  • Fushimi S, Nishikawa S, Shimazu A, Seto H.: Studies on new phosphate ester antifungal antibiotics phoslactomycins. I. Taxonomy, fermentation, purification and biological activities.
    J Antibiot, 42(7): 1019-1025 (1989) PMID: 2753808
  • Fushimi S, Furihata K, Seto H.: Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.
    J Antibiot, 42(7): 1026-1036 (1989) PMID: 2753809
  • biological activity
  • Usui T, Marriott G, Inagaki M, Swarup G, Osada H.: Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.
    J Biochem, 125(5): 960-965 (1999) PMID: 10220590
  • biosynthesis study
  • Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA.: Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.
    J Biol Chem, 278(37): 35552-35557 (2003) PMID: 12819191 [ doi: 10.1074/jbc.M305082200 ]
  • Sekiyama Y, Palaniappan N, Kim BS, Reynolds KA, Osada H
    Biosynthesis of phoslactomycins: cyclohexanecarboxylic acid as the starter unit.
    Tetrahedron,59, 7465-7471 (2003) [ doi: 10.1016/S0040-4020(03)01205-5 ]
  • Additional information