ケミカルバイオロジー研究グループ(終了)

RS-22A - C

Structure
A: NPEdia
B: NPEdia
C: NPEdia
RS-22
Producing organism
Streptomyces violaceusnigar
Biological activity
antimicrobial activity
Abstract
Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.
References
isolation and structural determination
  • Ubukata M, Shiraishi N, Kobinata K, Kudo T, Yamaguchi I, Osada H, Shen YC, Isono K.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.
    J Antibiot, 48(4): 289-292 (1995) PMID: 7775264
  • Ubukata M, Morita T, Osada H.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. II. Physico-chemical properties and structure elucidation.
    J Antibiot, 48(4): 293-299 (1995) PMID: 7775265
  • Additional information