ケミカルバイオロジー研究グループ（終了）
RK-1355A, B
- Structure
-
A:
B:
- Producing organism
- Streptomyces sp. RK88-1355
- Biological activity
- cytotoxicity, antimicrobial
- Abstract
- Two novel quinomycin derivatives, RK-1355A and B, were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot (NPPlot) screening. The structural elucidation of RK-1355A and B were established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage. They showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.
- References
-
- Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.: RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.
J Antibiot, 67(4): 323-329 (2014)
[ doi: 10.1038/ja.2013.144 ] - Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.: RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.