Original Articles 2021

  1. Kashiwa T, Motoyama T, Yoshida K, Yun CS, Osada H.: Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae.
    Biosci Biotechnol Biochem, [Epub ahead of print] (2021) PMID:34755835 [ doi: 10.1093/bbb/zbab195 ]
  2. Lopez JAV, Nogawa T, Yoshida K, Futamura Y, Osada H.: 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture.
    Biosci Biotechnol Biochem, [Epub ahead of print] (2021) PMID: 34734225 [ doi: 10.1093/bbb/zbab192 ]
  3. Kawatani M, Aono H, Shimizu T, Ohkura S, Hiranuma S, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Osada H.: Identification of dihydroorotate dehydrogenase inhibitors-indoluidins-that inhibit cancer cell growth.
    ACS Chem Biol, [Epub ahead of print] (2021) PMID: 34730931 [ doi: 10.1021/acschembio.1c00625 ]
  4. Zhu H, Cai Y, Ma S, Futamura Y, Li J, Zhong W, Zhang X, Osada H, Zou H.: Privileged Biorenewable Secologanin-Based Diversity-Oriented Synthesis for Pseudo-Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks.
    ChemSusChem, [Epub ahead of print] (2021) PMID: 34636473 [ doi: 10.1002/cssc.202101868 ]
  5. Liu H, Futamura Y, Wu H, Ishiyama A, Zhang T, Shi T, Zheng Q, Iwatsuki M, Ōmura S, Zou H, Osada H.: Discovery of 3-cinnamamido-N-substituted benzamides as potential antimalarial agents
    Med Chem, [Epub ahead of print] (2020) PMID: 32807065 [ doi: 10.2174/1573406416666200817160708 ]
  6. Jang JP, Kwon MC, Nogawa T, Takahashi S, Osada H, Ahn JS, Ko SK, Jang JH.: Thiolactomide: A New homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity.
    J Microbiol Biotechnol, [Epub ahead of print] (2021) PMID: 34528916 [ doi: 10.4014/jmb.2108.08015 ]
  7. Mendoza A, Takemoto Y, Cruzado KT, Masoud SS, Nagata A, Tantipanjaporn A, Okuda S, Kawagoe F, Sakamoto R, Odagi M, Mototani S, Togashi M, Kawatani M, Aono H, Osada H, Nakagawa H, Higashi T, Kittaka A, Nagasawa K, Uesugi M.: Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.
    Cell Chem Biol, [Epub ahead of print] (2021) PMID: 34506728 [ doi: 10.1016/j.chembiol.2021.08.008 ]
  8. Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R.: Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana.
    Sci Rep, 11(1): 21109 (2021) PMID: 34702872 [ doi: 10.1038/s41598-021-00564-4 ]
  9. Sakamoto T, Fukui Y, Kondoh Y, Honda K, Shimizu T, Hara T, Hayashi T, Saitoh Y, Murakami Y, Inoue JI, Kaneko S, Osada H, Seiki M.: Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock.
    Commun Biol, 4(1): 1165 (2021) PMID: 34621018 [ doi: 10.1038/s42003-021-02701-1 ]
  10. Motoyama T, Ishii T, Kamakura T, Osada H.: Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism.
    Biosci Biotechnol Biochem, 85(10): 2200-2208 (2021) PMID: 34379730 [ doi: 10.1093/bbb/zbab143 ]
  11. Safizadeh H, Simpkins SW, Nelson J, Li SC, Piotrowski JS, Yoshimura M, Yashiroda Y, Hirano H, Osada H, Yoshida M, Boone C, Myers CL.: Improving measures of chemical structural similarity using machine learning on chemical-genetic interactions.
    J Chem Inf Model, 61(9): 4156-4172 (2021) PMID: 34318674 [ doi: 10.1021/acs.jcim.0c00993 ]
  12. Yoshida K, Kondoh Y, Nakano T, Bolortuya B, Kawabata S, Iwahashi F, Nagano E, Osada H.: New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought.
    ACS Chem Biol, 16(8): 1566-1575 (2021) PMID: 34379974 [ doi: 10.1021/acschembio.1c00451 ]
  13. Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.: Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth.
    ACS Chem Biol, 16(8): 1576-1586 (2021) PMID: 34296611 [ doi: 10.1021/acschembio.1c00480 ]
  14. Miyazawa K, Asano Y, Tabuchi M, Kako S, Kawatani M, Osada H, Maeda H, Goto S.: Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice.
    J Pharmacol Sci, 147(1): 40-47 (2021) PMID: 34294371 [ doi: 10.1016/j.jphs.2021.05.011 ]
  15. Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A.: Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.
    Cancer Sci, [Epub ahead of print] (2021) PMID: 34289205 [ doi: 10.1111/cas.15079 ]
  16. Sakai K, Takao R, Koshino H, Futamura Y, Osada H, Takahashi S.: 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone.
    J Antibiot, [Epub ahead of print] (2021) PMID: 34234285 [ doi: 10.1038/s41429-021-00442-1 ]
  17. Rawa MSA, Nogawa T, Okano A, Futamura Y, Wahab HA, Osada H.: Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026.
    J Antibiot, 74(8): 485-495 (2021) PMID: 34163024 [ doi: 10.1038/s41429-021-00429-y ]
  18. Fujiyama K, Kato N, Re S, Kinugasa K, Watanabe K, Takita R, Nogawa T, Hino T, Osada H, Sugita Y, Takahashi S, Nagano S.: Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons.
    Angew Chem Int Ed Engl, [Epub ahead of print] (2021) PMID: 34121297 [ doi: 10.1002/anie.202106186 ]
  19. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y.: CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
    J Biol Chem, [Epub ahead of print] (2021) PMID: 34022224 [ doi: 10.1016/j.jbc.2021.100803 ]
  20. Takayama KI, Honma T, Suzuki T, Kondoh Y, Osada H, Suzuki Y, Yoshida M, Inoue S.: Targeting epigenetic and post-transcriptional gene regulation by PSF impairs hormone therapy-refractory cancer growth.
    Cancer Res, [Epub ahead of print] (2021) PMID: 33975881 [ doi: 10.1158/0008-5472.CAN-20-3819 ]
  21. Lopez JAV, Nogawa T, Futamura Y, Aono H, Hashizume D, Osada H.: N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647.
    J Antibiot, 74: 477–479 (2021) PMID: 33879862 [ doi: 10.1038/s41429-021-00420-7 ]
  22. Kako S, Tabuchi M, Miyazawa K, Tanaka M, Minamoto C, Asano Y, Kimura F, Aoki Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.: Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?
    Eur J Orthod, [Epub ahead of print] (2021) PMID: 33740062 [ doi: 10.1093/ejo/cjaa067 ]
  23. Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, Waldmann H.: Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.
    Cell Chem Biol, 28(6): 848-854.e5 (2021) PMID: 33567254 [ doi: 10.1016/j.chembiol.2021.01.009 ]
  24. Cheng L, Osada H, Xing T, Yoshida M, Xiang L, Qi J.: The insulin receptor: a potential target of amarogentin isolated from Gentiana rigescens franch that induces neurogenesis in PC12 cells.
    Biomedicines, 9(5): 581 (2021) PMID: 34065446 [ doi: 10.3390/biomedicines9050581 ]
  25. Miyazawa K, Asano Y, Tabuchi M, Kako S, Kawatani M, Osada H, Maeda H, Goto S.: Local administration of reveromycin A ointment suppressed alveolar bone loss in mice.
    J Pharmacol Sci, 147(1): 40-47 (2021) PMID: 34065446 [ doi: 10.1016/j.jphs.2021.05.011 ]
  26. Hara T, Toyoshima M, Hisano Y, Balan S, Iwayama Y, Aono H, Futamura Y, Osada H, Owada Y, Yoshikawa T.: Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons.
    Transl Psychiatry, 11(1): 275 (2021) PMID: 33966051 [ doi: 10.1038/s41398-021-01392-w ]
  27. Furuyama Y, Motoyama T, Nogawa T, Kamakura T, Osada H.: Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus.
    Biosci Biotechnol Biochem, 85(5): 1290-1293 (2021) PMID: 33784739 [ doi: 10.1093/bbb/zbab021 ]
  28. Watanabe K, Bat-Erdene A, Tenshin H, Cui Q, Teramachi J, Hiasa M, Oda A, Harada T, Miki H, Sogabe K, Oura M, Sumitani R, Mitsui Y, Endo I, Tanaka E, Kawatani M, Osada H, Matsumoto T, Abe M.: Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.
    Haematologica, 106(4): 1172-1177 (2021) PMID: 32586903 [ doi: 10.3324/haematol.2019.244418 ]
  29. Takao R, Sakai K, Koshino H, Osada H, Takahashi S.: Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator.
    Biosci Biotechnol Biochem, 85(3): 714-721 (2021) PMID: 33590007 [ doi: 10.1093/bbb/zbaa082 ]
  30. Furuyama Y, Motoyama T, Nogawa T, Hayashi T, Hirota H, Kiyota H, Kamakura T, Osada H.: Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase.
    Biosci Biotechnol Biochem, 85(1): 126-133 (2021) PMID: 33577666 [ doi: 10.1093/bbb/zbaa035 ]
  31. Rawa MSA, Nogawa T, Okano A, Futamura Y, Nakamura T, Wahab HA, Osada H.: A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening.
    Biosci Biotechnol Biochem, 85(1): 69-76 (2021) PMID: 33577647 [ doi: 10.1093/bbb/zbaa051 ]
  32. Jang M, Hara S, Kim GH, Kim SM, Son S, Kwon M, Ryoo IJ, Seo H, Kim MJ, Kim ND, Soung NK, Kwon YT, Kim BY, Osada H, Jang JH, Ko SK, Ahn JS.: Dutomycin induces autophagy and apoptosis by targeting the serine protease Inhibitor SERPINB6.
    ACS Chem Biol, 16(2): 360-370 (2021) PMID: 33517652 [ doi: 10.1021/acschembio.0c00889 ]
  33. Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.: Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
    Nat Chem Biol, 17(3): 335-343 (2021) PMID: 33168978 [ doi: 10.1038/s41589-020-00676-4 ]