Original Articles 2016

  1. Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL.: A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
    Nat Commun, 7: 13609 (2016) PMID: 28000660 [ doi: 10.1038/ncomms13609 ]
  2. Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.: Proteomic profiling reveals that collismycin A is an iron chelator.
    Sci Rep, 6: 38385 (2016) PMID: 27922079 [ doi: 10.1038/srep38385 ]
  3. Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama T
    Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces
    Nat Chem Biol , 12: 967–972 (2016) [ doi: 10.1038/nchembio.2181 ]
  4. Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.: Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.
    J Cell Biol, 215(1): 121-138 (2016) PMID: 27697926 [ doi: 10.1083/jcb.201604030 ]
  5. Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS.: Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.
    J Nat Prod, 79(10): 2703-2708 (2016) PMID: 27726391 [ doi: 10.1021/acs.jnatprod.6b00641 ]
  6. Shinohara Y, Takahashi S, Osada H, Koyama Y.: Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.
    Sci Rep, 6: 32865 (2016) PMID: 27628599 [ doi: 10.1038/srep32865 ]
  7. Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H.: Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ.
    Sci Rep, 6: 29881 (2016) PMID: 27431267 [ doi: 10.1038/srep29881 ]
  8. Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H.: High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.
    Biochem Biophys Res Commun, 477(4): 737-742 (2016) PMID: 27363336 [ doi: 10.1016/j.bbrc.2016.06.128 ]
  9. Yanai T, Kurosawa A, Nikaido Y, Nakajima N, Saito T, Osada H, Konno A, Hirai H, Takeda S.: Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.
    Genes Cells, 21(7): 717-727 (2016) PMID: 27184081 [ doi: 10.1111/gtc.12378 ]
  10. Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Ohno H, Osada H, Fujii N.: Screening of a virtual mirror-image library of natural products.
    Chem Commun (Camb), 52(49): 7653-7656 (2016) PMID: 27198617 [ doi: 10.1039/c6cc03114e ]
  11. Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H.: Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.
    Biochem Biophys Res Commun, 474(3): 528-533 (2016) PMID: 27120460 [ doi: 10.1016/j.bbrc.2016.04.124 ]
  12. Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.: Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
    Sci Rep, 6: 26521 (2016) PMID: 27210421 [ doi: 10.1038/srep26521 ]
  13. Nishiyama Y, Ohmichi T, Kazami S, Iwasaki H, Mano K, Nagumo Y, Kudo F, Ichikawa S, Iwabuchi Y, Kanoh N, Eguchi T, Osada H, Usui T.: Vicenistatin induces early endosome-derived vacuole formation in mammalian cells.
    Biosci Biotechnol Biochem, 80(5): 902-910 (2016) PMID: 27104762 [ doi: 10.1080/09168451.2015.1132152 ]
  14. Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H.: Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
    Cell Chem Biol, 23(4): 494-507 (2016) PMID: 27049670 [ doi: 10.1016/j.chembiol.2016.02.015 ]
  15. Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.: New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006.
    Mar Drugs, 14(4): (2016) PMID: 27049393 [ doi: 10.3390/md14040072 ]
  16. Lim CL, Nogawa T, Okano A, Futamura Y, Kawatani M, Takahashi S, Ibrahim D, Osada H.: Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library.
    J Antibiot, 69(6): 456-458 (2016) PMID: 26648115 [ doi: 10.1038/ja.2015.124 ]
  17. Katsuyama S, Sugino K, Sasazawa Y, Nakano Y, Aono H, Morishita K, Kawatani M, Umezawa K, Osada H, Simizu S.: Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.
    FEBS Lett, 590(8): 1152-1162 (2016) PMID: 27001232 [ doi: 10.1002/1873-3468.12146 ]
  18. Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.: Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast.
    Sci Rep, 6: 20856 (2016) PMID: 26892493 [ doi: 10.1038/srep20856 ]
  19. Aretz J, Kondoh Y, Honda K, Anumala UR, Nazaré M, Watanabe N, Osada H, Rademacher C.: Chemical fragment arrays for rapid druggability assessment.
    Chem Commun (Camb), 52(58): 9067-9070 (2016) PMID: 26890187 [ doi: 10.1039/c5cc10457b ]
  20. Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.: Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field.
    Phytochemistry, 122: 154-164 (2016) PMID: 26712614 [ doi: 10.1016/j.phytochem.2015.12.008 ]
  21. Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H, Suzu S.: Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages.
    J Immunol, 196(4): 1832-1841 (2016) PMID: 26773158 [ doi: 10.4049/jimmunol.1500845 ]
  22. Kakeya H, Kaida D, Sekiya H, Nagai K, Yoshida M, Osada H.: RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.
    J Antibiot, 69(2): 121-123 (2016) PMID: 26350783 [ doi: 10.1038/ja.2015.94 ]
  23. Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y.: An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae.
    J Antibiot, 69(1): 4-8 (2016) PMID: 26126743 [ doi: 10.1038/ja.2015.73 ]