Hiroyuki OSADA - Group Director

Hiroyuki OSADA
Hiroyuki OSADA

Deputy Director of RIKEN Center for Sustainable Resource Science
Group Director of Chemical Biology Research Group

INTEREST OF MY RESEARCH
I wonder why microorganisms produce various compounds with chemical and biological diversities. To resolve the mystery, I am interested in biosynthesis gene clusters of microorganisms. In addition, I want to contribute to the society through the chemical biology research with bioprobes and the molecular target therapy of tumors.
EDUCATION
1974-1978
The University of Tokyo, Department of Agricultural Chemistry
1978-1983
Graduate Course, The University of Tokyo, Faculty of Agricul
Dr. Agriculture (1983) The University of Tokyo
APPOINTMENTS
1983-1991
Scientist, Antibiotics Laboratory, RIKEN
1985-1986
Research Fellow, National Cancer Institute, NIH, USA.
1992-2015
Chief Scientist, Antibiotics Laboratory, RIKEN
1999- present
Visiting Professor, Saitama University
2009-2013
Director, Chemical Biology Core Facility, RIKEN ASI
2013- present
Director, Chemical Biology Research Group,
Deputy Director, RIKEN Center for Sustainable Resource Science
ACADEMIC ACTIVITIES
Editorial Board Member
  • Assay and Drug Development Technology
  • Cancer Science
  • Journal of Antibiotics
  • Journal of General and Applied Microbiology
  • Journal of Industrial Microbiology & Biotechnology
  • Journal of Microbiology and Biotechnology
  • Oncology Research
Advisory Board Member
  • ACS Chemical Biology
MY HOBBY

Chatting with drinking wine

AWARDS
  • Research Promotion Award of Agricultural Chemical Society of Japan (1991)
  • Sumiki-Umezawa Memorial Award from Japan Antibiotic Research Association (1996)
  • Award of the Society for Actinomycetes Japan (2000)
  • Award of the Minister of Education, Culture, Sports, Science and Technology (2001)
  • Award of the Bioindustry Association (2007)
  • Award of Agricultural Chemical Society of Japan (2009)
  • Significant Achievement Award (S) RIKEN (2010)
  • Inhoffen Medal (2015)
  • Special Award of Agricultural Chemical Society of Japan (2016)
SELECTED PAPERS
  1. Piotrowski, J. S. et al. Functional annotation of chemical libraries across diverse biological processes. Nature Chem Biol, 13, 982-993, (2017).
  2. Hasebe, F. et al. Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. Nature Chem Biol 12, 967-972, (2016).
  3. Ray, L. et al. A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Commun 7, 13609, (2016).
  4. Yun, C. S., Motoyama, T. & Osada, H. Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nature Commun 6, 8758, (2015).
  5. Soeda, Y. et al. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature Commun 6, 10216, (2015).
  6. Takahashi, S. et al. Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T. J Biol Chem 289, 32446-32458, (2014).
  7. Takahashi, S. et al. Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. Nature Chem Biol 7, 461-468, (2011).
  8. Sun, Y. et al. In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chem Biol 6, 99-101, (2010).
  9. Miyazaki, I. et al. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nature Chem Biol 6, 667-673, (2010).
  10. Yano, A. et al. Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. Proc. Natl. Acad. Sci., USA. 105, 15541-15546, (2008).
  11. Kawatani, M et al. The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. Proc. Natl. Acad. Sci., USA. 105, 11691-11696, (2008).
  12. Woo, J.-T. et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc. Natl. Acad. Sci., USA. 103, 4729-4734, (2006).
  13. Watanabe, N. et al. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc. Natl. Acad. Sci., USA. 102, 11663-11668 (2005).
  14. Watanabe, N. et al. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFB-TrCP. Proc. Natl. Acad. Sci., USA. 101, 4419-4424, (2004).
  15. Simizu, S. & Osada, H. Mutations in the Plk gene lead to instability of Plk protein in human tumor cell lines. Nature Cell Biol 2, 852-854, (2000).

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