Yasumitsu KONDOH

Yasumitsu KONDOH
Yasumitsu KONDOH
Chemical Biology Research Group

Treasure hunting finding lead compounds for drug discovery is very attractive. We have developed chemical array carrying more than 3,000 of small molecules on a chip and have screened binders of a protein of interest by using it as a tool. I want to find out novel lead compounds modulating the function of the protein from screened binders.

Nagoya University, Department of Molecular Biology
Research Student, Graduate School of Environmental Earth Science, Hokkaido University
B.Sc. (1991)
Nagoya University
Ph.D (1998)
Hokkaido University
Researcher, AISIN Seiki Co., Ltd.
Contract Researcher, Advanced Engineering Center, RIKEN
Research Scientist, Advanced Engineering Center, RIKEN
Research Scientist, Probing technology Laboratory, RIKEN
Senior Research Scientist, Probing technology Laboratory, RIKEN
Senior Research Scientist, Antibiotics Laboratory, RIKEN
Senior Research Scientist,Chemical Biology Core Facility, RIKEN ASI
Bio-Active Compounds Discovery Research Unit, Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science,
  • apan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Molecular Biology Society of Japan
Ski, Baseball, Badminton
  1. Kawamura T., Kondoh Y., Muroi M., Kawatani M., & Osada H. A small molecule that induces reactive oxygen species via cellular glutathione depletion. Biochemical Journal 463, 53-63 (2014).
  2. Yao R., Kondoh Y., Natsume Y., Yamanaka H., Inoue M., Toki H., Takagi R., Shimizu T., Yamori T., Osada H., & Noda T. A small compound targeting TACC3 revealed its spatiotemporally different contributions to the spindle assembly in cancer cells. Oncogene 33, 4242-4252 (2014).
  3. Hirohama M., Kumar A., Fukuda I., Matsuoka S., Igarashi Y., Saitoh H., Takagi M., Shin-ya K., Honda K., Kondoh Y., Saito T., Nakao Y., Osada H., Zhang K., Yoshida M., & Ito A. Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chemical Biology 8, 2635-2642 (2013).
  4. Nakajima Y., Kawamura T., Maeda K., Ichikawa H., Motoyama T., Kondoh Y., Saito T., Kobayashi T., Yoshida M., Osada H., & Kimura M. Identification and characterization of an inhibitor of trichothecene 3-O-acetyltransferase, TRI101, by the chemical array approach. Biosci Biotechnol Biochem, 77, 1958-1960 (2013).
  5. Noguchi T., Oishi S., Honda K., Kondoh Y., Saito T., Kubo T., Kaneda M., Ohno H., Osada H., & Fujii N.. Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidomimetic inhibitors. Bioorganic & Medicinal Chemistry Letters 23, 3802-3805 (2013).
  6. Kondoh Y. & Osada H. High-throughput screening identifies small molecule inhibitors of molecular chaperones. Current Pharmaceutical Design 19, 473-492 (2013).
  7. Zimmermann T.J., Burger M., Tashiro E., Kondoh Y., Martinez N.E., Gormer K., Rosin-steiner S., Shimizu T. Ozaki S., Mikoshiba K., Watanabe N., Hall D., Vetter I.R., Osada H., Hedberg C., & Waldmann H. Boronic acid inhibitors of acyl protein thioesterase 1 and 2. ChemBioChem 14, 115-122 (2013).
  8. Sasazawa Y., Kanagaki S., Tashiro E., Nogawa T., Muroi M., Kondoh Y., Osada H., & Imoto M. Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein. ACS Chemical Biology 7, 892-900 (2012).
  9. Burger M., Zimmermann T.J., Kondoh Y., Stege P., Watanabe N., Osada H., Waldmann, H., & Vetter, I.R. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity in spite of close relationship to acyl protein thioesterases. Journal of lipid research 53, 43-50 (2012).
  10. Minagawa S., Kondoh Y., Sueoka K., Osada H., & Nakamoto H. Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity. Biochemical Journal 435, 237-246 (2011).
  11. Hagiwara K., Kondoh Y., Ueda A., Yamada K., Goto H., Watanabe T., Nakata T., Osada H., & Aida Y. Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays. Biochemical Biophysical Research Communications 394, 721-727 (2010).
  12. Hagiwara K., Murakami T., Xue G., Shimizu Y., Takeda E., Hashimoto Y., Honda K., Kondoh Y., Osada H., Tsunetsugu-Yokota Y., & Aida Y. Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array. Biochemical Biophysical Research Communications, 403, 40-45 (2010).

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