Yasumitsu KONDOH

Yasumitsu KONDOH
Yasumitsu KONDOH
Chemical Biology Research Group
INTEREST OF MY RESEARCH

Treasure hunting finding lead compounds for drug discovery is very attractive. We have developed chemical array carrying more than 3,000 of small molecules on a chip and have screened binders of a protein of interest by using it as a tool. I want to find out novel lead compounds modulating the function of the protein from screened binders.

EDUCATION
1987-1991
Nagoya University, Department of Molecular Biology
1994-1999
Research Student, Graduate School of Environmental Earth Science, Hokkaido University
DEGREES
B.Sc. (1991)
Nagoya University
Ph.D (1998)
Hokkaido University
APPOINTMENTS
1991-1999
Researcher, AISIN Seiki Co., Ltd.
1999-2001
Contract Researcher, Advanced Engineering Center, RIKEN
2001-2003
Research Scientist, Advanced Engineering Center, RIKEN
2003-2005
Research Scientist, Probing technology Laboratory, RIKEN
2005-2007
Senior Research Scientist, Probing technology Laboratory, RIKEN
2007-
Senior Research Scientist, Antibiotics Laboratory, RIKEN
2009.Oct.-2013
Senior Research Scientist,Chemical Biology Core Facility, RIKEN ASI
2013.Apr.-
Bio-Active Compounds Discovery Research Unit, Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science,
ACADEMIC ACTIVITIES
  • apan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Molecular Biology Society of Japan
MY HOBBY
Ski, Baseball, Badminton
LIST OF SELECTED PUBLICATIONS
  1. Kawamura T., Kondoh Y., Muroi M., Kawatani M., & Osada H. A small molecule that induces reactive oxygen species via cellular glutathione depletion. Biochemical Journal 463, 53-63 (2014).
  2. Yao R., Kondoh Y., Natsume　Y., Yamanaka H., Inoue M., Toki H., Takagi R., Shimizu T., Yamori T., Osada H., & Noda T. A small compound targeting TACC3 revealed its spatiotemporally different contributions to the spindle assembly in cancer cells. Oncogene 33, 4242-4252 (2014).
  3. Hirohama M., Kumar A., Fukuda I., Matsuoka S., Igarashi Y., Saitoh H., Takagi M., Shin-ya K., Honda K., Kondoh Y., Saito T., Nakao Y., Osada H., Zhang K., Yoshida M., & Ito A. Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chemical Biology 8, 2635-2642 (2013).
  4. Nakajima Y., Kawamura T., Maeda K., Ichikawa H., Motoyama T., Kondoh Y., Saito T., Kobayashi T., Yoshida M., Osada H., & Kimura M. Identification and characterization of an inhibitor of trichothecene 3-O-acetyltransferase, TRI101, by the chemical array approach. Biosci Biotechnol Biochem, 77, 1958-1960 (2013).
  5. Noguchi T., Oishi S., Honda K., Kondoh Y., Saito T., Kubo T., Kaneda M., Ohno H., Osada H., & Fujii N.. Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidomimetic inhibitors. Bioorganic & Medicinal Chemistry Letters 23, 3802-3805 (2013).
  6. Kondoh Y. & Osada H. High-throughput screening identifies small molecule inhibitors of molecular chaperones. Current Pharmaceutical Design 19, 473-492 (2013).
  7. Zimmermann T.J., Burger M., Tashiro E., Kondoh Y., Martinez N.E., Gormer K., Rosin-steiner S., Shimizu T. Ozaki S., Mikoshiba K., Watanabe N., Hall D., Vetter I.R., Osada H., Hedberg C., & Waldmann H. Boronic acid inhibitors of acyl protein thioesterase 1 and 2. ChemBioChem 14, 115-122 (2013).
  8. Sasazawa Y., Kanagaki S., Tashiro E., Nogawa T., Muroi M., Kondoh Y., Osada H., & Imoto M. Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein. ACS Chemical Biology 7, 892-900 (2012).
  9. Burger M., Zimmermann T.J., Kondoh Y., Stege P., Watanabe N., Osada H., Waldmann, H., & Vetter, I.R. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity in spite of close relationship to acyl protein thioesterases. Journal of lipid research 53, 43-50 (2012).
  10. Minagawa S., Kondoh Y., Sueoka K., Osada H., & Nakamoto H. Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity. Biochemical Journal 435, 237-246 (2011).
  11. Hagiwara K., Kondoh Y., Ueda A., Yamada K., Goto H., Watanabe T., Nakata T., Osada H., & Aida Y. Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays. Biochemical Biophysical Research Communications 394, 721-727 (2010).
  12. Hagiwara K., Murakami T., Xue G., Shimizu Y., Takeda E., Hashimoto Y., Honda K., Kondoh Y., Osada H., Tsunetsugu-Yokota Y., & Aida Y. Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array. Biochemical Biophysical Research Communications, 403, 40-45 (2010).

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