Tatsuro KAWAMURA


Tatsuro KAWAMURA (Ph.D.)

INTEREST OF MY RESEARCH

My research interest is in the diversity of the molecular mechanisms underlying the redox regulation and metabolism in cancer cells. For better understanding of the cellular redox regulation systems and application to disease treatment, I have been working on identification and characterization of small-molecule redox modulators.

EDUCATION

2001-2005 Keio University, Department of Science and Technology
2005-2010 Graduate Course, Keio University, Faculty of Science and Technology

DEGREES

B. Engineering (2005) Keio University
Dr. Engineering (2010) Keio University

APPOINTMENTS

2007 (Oct.) - 2010 (Mar.) Research Assistant, Global COE Program, Keio University
2010 (Apr.) - 2013 (Mar.) Postdoctoral Researcher, Chemical Biology Core Facility, RIKEN ASI
2013 (Apr.) - 2015 (Mar.)Special Postdoctoral Researcher, Antibiotics Laboratory, RIKEN
2015 (Apr.) – 2015 (Sep.)Special Postdoctoral Researcher, Chemical Biology Research Group, RIKEN CSRS
2015 (Oct.) – 2016 (Sep.)SContract Researcher, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster
2016 (Oct.) – 2017 (Mar.)Postdoctoral Fellow, Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Germany
[2015 (Sep.) – 2017 (Mar.)Worked in Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Germany]
2017 (Apr.) –Research Scientist, RIKEN-Max Planck Joint Research Division for Systems Chemical Biology, RIKEN CSRS

ACADEMIC ACTIVITIES

  • Japan Society for Bioscience Biotechnology, and Agrochemistry (JSBBA)
  • The Japan Association for Molecular Target Therapy of Cancer (JAMTTC)
  • Japanese Cancer Association (JCA)

MY HOBBY

Playing Sports

LIST OF SELECTED PUBLICATIONS

  1. Julian Wilke, Tatsuro Kawamura, Nobumoto Watanabe, Hiroyuki Osada, Slava Ziegler, Herbert Waldmann. Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion. Bioorg. Med. Chem. 26, 1453-1461 (2018)
  2. Ashutosh Kumar, Tatsuro Kawamura, Makoto Kawatani, Hiroyuki Osada, Kam Y. J. Zhang. Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors. Chem. Biol. Drug Des. 89, 862-869 (2017)
  3. Tatsuro Kawamura, Makoto Kawatani, Makoto Muroi, Yasumitsu Kondoh, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, Hiroyuki Osada. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. Sci. Rep. 6, 26521 (2016)
  4. Tatsuro Kawamura, Yasumitsu Kondoh, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada,
 A small molecule that induces reactive oxygen species via cellular glutathione depletion. Biochem. J. 463, 53-63 (2014)
  5. Yuichi Nakajima, Tatsuro Kawamura, Kazuyuki Maeda, Hinayo Ichikawa, Takayuki Motoyama, Yasumitsu Kohdoh, Tamio Saito, Tetsuo Kobayashi, Minoru Yoshida, Hiroyuki Osada, Makoto Kimura,
Identification and characterization of an inhibitor of trichothecene 3-O-acetyltransferase, TRI101, by the chemical array approach. Biosci. Biotechnol. Biochem. 77, 1958-1960 (2013)
  6. Tatsuro Kawamura, Kohei Matsubara, Hitomi Otaka, Etsu Tashiro, Kazutoshi Shindo, Ryo C. Yanagita, Kazuhiro Irie, Masaya Imoto, Generation of `Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP. Bioorg. Med. Chem. 19, 4377-4385 (2011)
  7. Tatsuro Kawamura, Takahiro Fujimaki, Natsuki Hamanaka, Kentaro Torii, Hiroki Kobayashi, Yoshikazu Takahashi, Masayuki Igarashi, Naoko Kinoshita, Yoshio Nishimura, Etsu Tashiro, Masaya Imoto, Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1. J. Antibiot. 63, 601-605 (2010)
  8. Tatsuro Kawamura, Etsu Tashiro, Kohta Yamamoto, Kazutoshi Shindo, Masaya Imoto, SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation, I. Taxonomy, fermentation, isolation, biological activities and SAR study. J. Antibiot. 61, 303-311 (2008)
  9. Tatsuro Kawamura, Etsu Tashiro, Kazutoshi Shindo, Masaya Imoto, SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation, II. Structure elucidation. J. Antibiot. 61, 312-317 (2008)

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