(Ph.D, Postdoctoral Researcher)


I have always imagined achieving the chemical biology study like Dr. Schreiber did using immuno-suppressive drug, FK506. What should I do for that? In general, chemical biology study starts by searching for unique bioactive compounds. I'm interested in cell morphology and also believe the microorganisms can produce many other compounds with chemical and functional diversities. I'm thus searching for fruitful bioactive compounds on the basis of their ability to alter cellular morphology from secondary metabolites of microorganisms.


1998-2002 Keio University, Department of Applied Chemistry
2002-2008 Graduate Course, Keio University, Faculty of Science and Technology


B.Sc. (2002) Keio University
Dr. Science (2008) Keio University


2008-2008 Post Doctoral Fellow, Antibiotics Laboratory, RIKEN ASI
2008-2015 Special Post Doctoral Researcher, Antibiotics Laboratory, RIKEN ASI
2009-2013 Special Post Doctoral Researcher,Chemical Biology Core Facility, RIKEN ASI
2015.Apr.- RIKEN Center for Sustainable Resource Science - Chemical Biology Research Group


  • JCA
  • Japanese Society for Chemical Biology


golf, lusty-singing


  1. Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
    Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.
    Biochim. Biophys. Acta. (2018) in press
  2. Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.
    Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.
    Chem. Sci. (2018) 9: 3014-3022.
  3. Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K.
    Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.
    Sci. Rep. (2018) 8: 2769.
  4. Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, Imoto M.
    Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.
    Cancer Sci (2017) 108: 772-784.
  5. Futamura Y, Yamamoto K, Osada H.
    Phenotypic screening meets natural products in drug discovery.
    Biosci Biotechnol Biochem (2017) 81: 28-31.
  6. Minegishi H, Futamura Y, Fukashiro S, Muroi M, Kawatani M, Osada H, Nakamura H.
    Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.
    J. Med. Chem. (2015) 58: 4230-4241.
  7. Futamura Y, Kawatani M, Muroi M, Nogawa T, Aono H, Osada H.
    Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.
    ChemBioChem (2013) 18: 2456-2463.
  8. Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H.
    Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.
    Chem. Biol. (2012) 19: 1620-1630. COVER Image
  9. Sasazawa Y, Futamura Y, Tashiro E, Imoto M.
    V-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway.
    Cancer Science (2009) 100: 1460-1467.
  10. Futamura Y, Sawa R, Umezawa Y, Igarashi M, Nakamura H, Hasegawa K, Yamasaki M, Tashiro E, Takahashi Y, Akamatsu Y, Imoto M.
    Discovery of Incednine as a Potent Modulator of the Anti-apoptotic Function of Bcl-xL from Microbial Origin.
    J. Am. Chem. Soc (2008) 130: 1822-1823.

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