(Ph.D, Special Temporary Employee)


Microorganisms produce various compounds with chemical and biological diversities. I want to chemically synthesize useful compounds which microorganisms can not produce.


1967-1971Tohoku University, Department of Pharmaceutical Sciences
1971-1973Tohoku University, Faculty of Pharmaceutical Sciences


B.Sc. (1971) Tohoku University 
Dr. Pharmacy (1979) Tohoku University 


1973-Reserch Scientist, Synthetic Pesticide Laboratory I, RIKEN
1981-1983Research Fellow, Columbia University, USA.
1992- Senior Reserch Scientist, RIKEN
1998-2001 Visiting Professor, Rikkyo University
2001- present Visiting Professor, Tokyo Denki University
2001-2009 Senior Scientist, Synthetic Organic Chemistry, RIKEN
2004-2008Team Leader, RIKEN Chemical Biology Group
2009-2009Special Temporary Employee, RIKEN Chemical Biology Department
2009-2013Special Temporary Employee,Chemical Biology Core Facility, RIKEN ASI  
2013-2015Special Temporary Employee, Antibiotics Lab.
2015.Apr.-RIKEN Center for Sustainable Resource Science - Chemical Biology Research Group


  • The Pharmaceutical Society of Japan
  • The Society of Synthetic Organic Chemistry, Japan
  • Japanese Society for Chemical Biology<




  1. Nogawa, T., Kato,, N., Shimizu, T., Okano, A., Futamura, Y., Takahashi, S., Osada, H.,
    "Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058"
    J. Antibiot. 2018, 71, 123-128.

  2. Kondoh, Y.; Honda, K.; Hiranuma, H.; Hayashi, T.; Shimizu, T.; Watanabe, N.; Osada, H.
    "Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ" Sci. Rep. 2016, 6, 29881.

  3. Subedi, A.; Shimizu, T.; Ryo, A.; Sanada, E.; Osada, H., Watanabe, N. “Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening” Biochem. Biophysic. Res. Commun. 2016, 474, 528-533.

  4. Yao, R.; Kondoh, Y.; Natsume, Y.; Yamanaka, H.; Inoue, M.; Toki, H.; Takagi, R.; Shimizu, T.; Yamori, T.; Osada, H.; Noda, T. " A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells" Oncogene. 2013, 14, 4242-4252.

  5. Zimmermann, T. J.; Bürger, M.; Tashiro, E.; Kondoh, Y.; Martinez, N. E.; Görmer, K.; Rosin-Steiner, S.; Shimizu, T.; Ozaki, S.; Mikoshiba, K.; Watanabe, N.; Hall, D.; Vetter, I. R.; Osada, H.; Hedberg, C., Waldmann, H. " Boron-Based Inhibitors of Acyl Protein Thioesterase 1 and 2" ChemBioChem. 2013, 14, 115-122.

  6. Kahn, M. M. G.; Simizu, S; Lai, N. S.; Kawatani, M.; Shimizu, T.; Osada, H. " Discovery of a Small Molecule PDI Inhibitor that Inhibits Reduction of HIV-1 Envelope Gycoprotein gp120 ", Chem. Biol. 2011, 6, 245-251.

  7. Shimizu, T.; Usui, T.; Fujikura, M.; Kawatani, M.; Satoh, T.; Machida, K.; Kanoh, N.; Woo, J-T.; Osada, H.; Sodeoka, M. "Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives", Bioorg. Med. Chem. Lett. 2008, 18, 3756-3760.

  8. Shimizu, T.; Satoh, T.; Murakoshi, K.; Sodeoka, M. " Asymmetric Total Synthesis of (-)-Spirofungin A and (+)-Spirofungin B ", Org. Lett. 2005, 7, 4965-4968.

  9. Shimizu, T.; Masuda, T.; Hiramoto, K.; Nakata, T. "Total Synthesis of Reveromysin A ", Org. Lett. 2000, 2, 2153-2156.

  10. Shimizu, T.; Ohzeki, T.; Hiramoto, K.; Hori, N.; Nakata, T. " Chloromethanesulfonate as an Efficient Leaving Group: Rearrangement of the Carbon-Carbon Bond and Conversion of Alcohols into Azides and Nitrils ", Synthesis 1999, 1373-1385.

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