Takayuki MOTOYAMA
Takayuki MOTOYAMA
(Ph.D,Senior Research Scientist)
INTEREST OF MY RESEARCH
Filamentous fungi (molds) are well known as plant and animal pathogens and mycotoxin producers. On the other hand, filamentous fungi are useful in production of fermentation foods (sake etc.) and medicines. Recently, it has become apparent that huge numbers of secondary metabolism genes of unknown functions are sleeping in the genomes of filamentous fungi. Aims of my research are to develop medicines by using these genes and to develop agrochemicals that control production of fungal secondary metabolites required for pathogenicity.
EDUCATION
| 1986-1990 | The University of Tokyo, Department of Agricultural Chemistry |
| 1990-1996 | Graduate Course, The University of Tokyo, Faculty of Agriculture |
DEGREES
| B.Sc. (1990) | The University of Tokyo |
| Dr. Agriculture (1995) | The University of Tokyo |
APPOINTMENTS
| 1995-2002 | Scientist, Microbial Toxicology Lab., RIKEN |
| 2002-2008 | Senior Scientist, Environmental Molecular Biology Lab., RIKEN |
| 2008-2015 | Senior Scientist, Antibiotics Lab., RIKEN | 2014.Feb.- | RIKEN Center for Sustainable Resource Science - Chemical Biology Research Group |
ACADEMIC ACTIVITIES
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Fungal Molecular Biology Society of Japan
- Japanese Society for Chemical Biology
MY HOBBY
Appreciation and using of ceramic arts, cat
LIST OF SELECTED PUBLICATIONS
- Yun, C.-S, Motoyama, T. amd Osada, H.: "Regulatory mechanism of mycotoxin tenuazonic acid production in Pyricularia oryzae", ACS Chem Biol, 12: 2270-2274 (2017).
Press release: http://www.riken.jp/pr/press/2017/20171006_1/ - Yun, C.-S., Motoyama, T. and Osada, H.: "Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme", Nat Commun, 6: 8758 (2015).
Press release: http://www.riken.jp/pr/press/2015/20151027_1/ - Motoyama, T., Hayashi, T., Hirota, H., Ueki, M. and Osada, H.:"
Terpendole E, a Kinesin Eg5 Inhibitor, Is a Key Biosynthetic Intermediate of Indole-Diterpenes in the Producing Fungus Chaunopycnis alba", Chemistry & Biology, 19: 1611-1619, (2012).
Press release: http://www.riken.jp/pr/press/2012/20121221_2/ - Vetcher,, L., Hugo G. Menzella, H.G., Kudo, T., Motoyama, T., and Katz, L.: “ The Antifungal Polyketide Ambruticin Targets the HOG Pathway”, Antimicrob. Agents Chemother., 51: 3734-3736 (2007).
- Motoyama, T., Ohira, T., Kadokura, K., Ichiishi, A., Fujimura, M., Yamaguchi, I., Kudo, T.: “An Os-1 family histidine kinase from a filamentous fungus confers fungicide-sensitivity to yeast ”, Curr. Genet., 47: 298-306 (2005).