Kinanthraquinone
- Structure
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- Producing organism
- Streptomyces reveromyceticus SN-593-44
- Biological activity
- cytotoxocity
- Abstract
- A new anthraquinone derivative, kinanthraquinone was isolated from Streptomyces reveromyceticus SN-593-44. Its structure was determined by the combination of spectroscopic methods including NMR and MS. Kinanthraquinone had a characteristic carboxamide group and was a rare class of metabolite as an anthraquinone derivative isolated from microbes. It showed moderate cytotoxocity against HL-60 and srcts-NRK cell with IC50 value of 7.9 and 10 μM, respectively.
- References
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- Takagi H, Nogawa T, Futamura Y, Takahashi S, Osada H.: Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44.
J Antibiot, 71, 480-482 (2018)
[ doi: 10.1038/s41429-017-0020-0 ]
- Takagi H, Nogawa T, Futamura Y, Takahashi S, Osada H.: Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44.