Kinanthraquinone

Structure
NPEdia
Producing organism
Streptomyces reveromyceticus SN-593-44
Biological activity
cytotoxocity
Abstract
A new anthraquinone derivative, kinanthraquinone was isolated from Streptomyces reveromyceticus SN-593-44. Its structure was determined by the combination of spectroscopic methods including NMR and MS. Kinanthraquinone had a characteristic carboxamide group and was a rare class of metabolite as an anthraquinone derivative isolated from microbes. It showed moderate cytotoxocity against HL-60 and srcts-NRK cell with IC50 value of 7.9 and 10 μM, respectively.
References
  • Takagi H, Nogawa T, Futamura Y, Takahashi S, Osada H.: Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44.
    J Antibiot, 71, 480-482 (2018) PMID: 29410517 [ doi: 10.1038/s41429-017-0020-0 ]
  • Additional information