Hitoyol A, B

A: NPEdia
B: NPEdia
Hitoyol A Hitoyol B
Producing organism
Coprinopsis cinerea (NBRC 100011)
Biological activity
hitoyol A, no activities
hitoyol B, weak anti-malarial activity
Hitoyol A and B, isolated from the culture broth of Basidiomycete Coprinopsis cinerea (NBRC 100011), are novel skeletal norsesquiterpenoids. Their structures and absolute configurations were determined by the extensive spectroscopic analyses including X-ray and ECD. Hitoyol A was possibly biosynthesized from a known sesquiterpenoid lagopodin B via a decarboxylation-induced cyclization. Hitoyol B showed weak anti-malarial activity (IC50 = 59 μM).
Isolation, identification, and biological activities
  • Otaka J, Hashizume D, Masumoto Y, Muranaka A, Uchiyama M, Koshino H, Futamura Y, Osada H.: Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea.
    Org Lett, 19(15), 4030–4033 (2017) PMID: 28726419 [ doi: 10.1021/acs.orglett.7b01784 ]
  • Additional information