Opantimycin A

Producing organism
Streptomyces sp. RK88-1355
Biological activity
cytotoxicity and antimalarial activity
A new metabolite containing a γ-butyrolactone and 2-hydroxy-3- formylaminobenzoic acid moieties, opantimycin A was isolated from a microbial metabolite fraction library generated from Streptomyces sp. RK88-1355 by search of an LC/MS-based spectral database named NPPlot: Natural Products Plot. The structure was determined based on extensive spectroscopic methods including NMR, MS and MS/MS experiments. It showed moderate cytotoxicity against HL-60 cell lines and antimalarial activity against Plasmodium falciparum 3D7.
isolation and structural determination
  • Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H.: Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.
    J Antibiot, 70(2): 222-225 (2017) PMID: 27599762 [ doi: 10.1038/ja.2016.113 ]
  • Additional information