Opantimycin A
- Structure
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- Producing organism
- Streptomyces sp. RK88-1355
- Biological activity
- cytotoxicity and antimalarial activity
- Abstract
- A new metabolite containing a γ-butyrolactone and 2-hydroxy-3- formylaminobenzoic acid moieties, opantimycin A was isolated from a microbial metabolite fraction library generated from Streptomyces sp. RK88-1355 by search of an LC/MS-based spectral database named NPPlot: Natural Products Plot. The structure was determined based on extensive spectroscopic methods including NMR, MS and MS/MS experiments. It showed moderate cytotoxicity against HL-60 cell lines and antimalarial activity against Plasmodium falciparum 3D7.
- References
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isolation and structural determination
- Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H.: Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.
J Antibiot, 70(2): 222-225 (2017)
[ doi: 10.1038/ja.2016.113 ] - Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H.: Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.