Verticilactam
- Structure
- Producing organism
- Streptomyces spiroverticillatus JC-8444
- Biological activity
- no antibacterial, antifungal and cytotoxic activities.
- Abstract
- Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
- References
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- Nogawa T, Okano A, Takahashi S, Uramoto M, Konno H, Saito T, Osada H.: Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.
Org Lett, 12(20): 4564-4567 (2010)
[ doi: 10.1021/ol1018618 ] - Nogawa T, Okano A, Takahashi S, Uramoto M, Konno H, Saito T, Osada H.: Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.