Terpeptin
- Structure
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- Producing organism
- Aspergillus terreus
- Biological activity
- cell cycle inhibition
- Abstract
- Terpeptin, a novel peptide having cell cycle inhibitory activity, was isolated from the cultured broth of Aspergillus terreus 95F-1 and its structure was elucidated by spectral analyses. Terpeptin inhibited the cell cycle progression of mouse tsFT210 cells in the G2/M phase with a minimum inhibitory concentration of 62.5 µM.
- References
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isolation and structural determination
- Kagamizonoa T, Sakai N, Arai K, Kobinata K, Osada H.
Terpeptin, A Novel Mammalian Cell Cycle Inhibitor, Produced by Aspergillus terreus 95F-1
Tetrahedron Lett. 38, 1223-1226 (1997) [ doi: 10.1016/S0040-4039(97)00022-1 ] - Kagamizonoa T, Sakai N, Arai K, Kobinata K, Osada H.