NPEdia Terpeptin
Producing organism
Aspergillus terreus
Biological activity
cell cycle inhibition
Terpeptin, a novel peptide having cell cycle inhibitory activity, was isolated from the cultured broth of Aspergillus terreus 95F-1 and its structure was elucidated by spectral analyses. Terpeptin inhibited the cell cycle progression of mouse tsFT210 cells in the G2/M phase with a minimum inhibitory concentration of 62.5 µM.
isolation and structural determination
  • Kagamizonoa T, Sakai N, Arai K, Kobinata K, Osada H.
    Terpeptin, A Novel Mammalian Cell Cycle Inhibitor, Produced by Aspergillus terreus 95F-1
    Tetrahedron Lett. 38, 1223-1226 (1997) [ doi: 10.1016/S0040-4039(97)00022-1 ]
  • Additional information