Tautomycin
- Structure
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- Producing organism
- Streptomyces sp.
- Biological activity
- protein phosphatase type 1 inhibitor
- Abstract
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- References
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isolation and structural determination
- Cheng XC, Kihara T, Kusakabe H, Magae J, Kobayashi Y, Fang RP, Ni ZF, Shen YC, Ko K, Yamaguchi I.: A new antibiotic, tautomycin.
J Antibiot, 40(6): 907-909 (1987)
- Cheng XC, Ubukata M, Isono K.: The structure of tautomycin, a dialkylmaleic anhydride antibiotic.
J Antibiot, 43(7): 809-819 (1990)biological activity- Magae J, Watanabe C, Osada H, Cheng XC, Isono K.: Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.
J Antibiot, 41(7): 932-937 (1988)- Magae J, Osada H, Nagai K, Yamasaki M, Isono K.: Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system.
J Antibiot, 42(8): 1290-1293 (1989)- Magae J, Hino A, Isono K, Nagai K.: Respiratory burst induced by phorbol ester in the presence of tautomycin, a novel inhibitor of protein phosphatases.
J Antibiot, 45(2): 246-251 (1992)- Kurisaki T, Magae J, Isono K, Nagai K, Yamasaki M.: Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules.
J Antibiot, 45(2): 252-257 (1992)- Kurisaki T, Magae J, Nagai K, Hirata A, Kusaka I, Shinji H, Morikawa M, Yoshida T, Isono K, Yamasaki M.: Morphological changes and reorganization of actinfilaments in human myeloid leukemia cells induced by a novel protein phosphatase inhibitor, tautomycin.
Cell Struct Funct, 18(1): 33-39 (1993)structure-activity relationship- Nishiyama U, Ubukata M, Magae J, Kataoka T, Erdödi F, Hartshorne DJ, Isono K, Nagai K, Osada H.: Structure-activity relationship within a series of degradation products of tautomycin.
Biosci Biotechnol Biochem, 60(1): 103-107 (1996) [ doi: 10.1271/bbb.60.103 ]- Oikawa H.: Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study.
Curr Med Chem, 9(22): 2033-2053 (2002) - Cheng XC, Kihara T, Kusakabe H, Magae J, Kobayashi Y, Fang RP, Ni ZF, Shen YC, Ko K, Yamaguchi I.: A new antibiotic, tautomycin.