Spirotoamide A, B

A: NPEdia
Spirotoamide A
B: NPEdia
Spirotoamide B
Producing organism
Streptomyces griseochromogenes JC82-1223
Biological activity
(no antibacterial, antifungal, and cytotoxic activities)
Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compounds based on a search of spectral database. The fraction library was constructed using a systematic separation method to efficiently discover new metabolites from microbial sources such as actinomycetes and fungi. The structures of 1 and 2 were elucidated by 2D-NMR and mass spectrometric measurements. They belong to a class of polyketides, and contain a 6,6-spiroacetal core structure and a carboxamide group. The biosynthetic pathway of 1 and 2 is discussed in the text.
  • Nogawa T, Takahashi S, Okano A, Kawatani M, Uramoto M, Saito T, Osada H.: Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library.
    J Antibiot, 65(3): 123-128 (2012) PMID: 22186593 [ doi: 10.1038/ja.2011.121 ]
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