NPEdia (Re-discovered compound)
Producing organism
Streptomyces sp.
Biological activity
inhibitor of protein kinase C
During the screening for the inhibitors of protein kinase C (PKC), we found that a streptomycete produced an inhibitor in our bleb-forming assay (Osada et al., J. Antibiotics 41: 925, 1988). The inhibitor was isolated and identified as sangivamycin (4-amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine). Biological activity of sangivamycin was compared with that of other 7-deazaadenosine group antibiotics, tubercidin and toyocamycin. Sangivamycin showed a strong inhibitory activity against bleb-formation of K562 cells and PKC. On the other hand, tubercidin and toyocamycin had only weak activities in both assays. This paper deals with a new biological activity of sangivamycin, that of an inhibitor of protein kinases, especially PKC.
isolation and structural determination
  • Rao KV.: Structure of sangivamycin.
    J Med Chem, 11(5): 939-941 (1968) PMID: 5748694
  • biological activity
  • Osada H, Sonoda T, Tsunoda K, Isono K.: A new biological role of sangivamycin; inhibition of protein kinases.
    J Antibiot, 42(1): 102-106 (1989) PMID: 2921215
  • Additional information