RK-1441A, B

A: NPEdia
B: NPEdia
Producing organism
Streptomyces sp.
Biological activity
antibacteriophage activity
Streptomyces griseus and bacteriophage B were used for an assay system detecting anti-bacteriophage antibiotics. Streptomyces sp. RK-1441 was found to produce antibacteriophage antibiotics, RK-1441A and B, which are pyrrolo[1,4]benzodiazepine group antibiotics related to neothramycin. Both RK-1441A and B had antibacteriophage activity. The former showed antimicrobial activity on a hypersensitive strain of E. coli for antitumor antibiotics, but the later did not show the activity. Restriction enzyme assay suggested that RK-1441A formed adducts with guanine residues in DNA strands. RK-1441B was not active in vitro, but it might be converted to the active form in host organisms.
isolation and structural determination
  • Osada H, Ishinabe K, Yano T, Kajikawa K, Isono K.: New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties.
    Agric Biol Chem, 54(11): 2875-2881 (1990) PMID: 1369312
  • Additional information