RK-1409A, B
- Structure
-
A:
B:
- Producing organism
- Streptomyces platensis subsp. malvinus RK-1409
- Biological activity
- inhibitor of protein kinase C
- Abstract
- A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12,13-dibutyrate (PDBu) at the concentration of 10 ng/ml. The concentration of 3 ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells.
- References
-
isolation and structural determination
- Osada H, Koshino H, Kudo T, Onose R, Isono K.: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.
J Antibiot, 45(2): 189-194 (1992)
- Koshino H, Osada H, Isono K.: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.
J Antibiot, 45(2): 195-198 (1992)- Koshino H, Osada H, Amano S, Onose R, Isono K.: A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).
J Antibiot, 45(9): 1428-1432 (1992) - Osada H, Koshino H, Kudo T, Onose R, Isono K.: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.