Respinomycin A1, A2, B, C, D

A1 A -Me R3 NPEdia
A2 A -Me -H NPEdia
B -H -H -R NPEdia
C -H -Me -R NPEdia
D D -Me -R NPEdia
Producing organism
Streptomyces xanthocidicus (isolated in Nagano, Japan)
Biological activity
induction of cell differentiaion, antiphage activity
Respinomycins are a novel group of anthracycline antibiotics produced by Streptomyces xanthocidicus. Respinomycins A1, A2, B, C and D were isolated by EtOAc extraction, silica gel column chromatography, centrifugal partition chromatography and preparative silica gel thin layer chromatography. Respinomycins A1 and A2 induced the terminal differentiation of human leukemia K-562 cells.
isolation and structural determination
  • Ubukata M, Tanaka C, Osada H, Isono K.: Respinomycin A1, a new anthracycline antibiotic.
    J Antibiot, 44(11): 1274-1276 (1991) PMID: 1761426
  • Ubukata M, Osada H, Kudo T, Isono K.: Respinomycins A1, A2 B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities.
    J Antibiot, 46(6): 936-941 (1993) PMID: 8344875
  • Ubukata M, Uzawa J, Osada H, Isono K.: Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation.
    J Antibiot, 46(6): 942-951 (1993) PMID: 8344876
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