Phosphatoquinone A, B

A: NPEdia
B: NPEdia
Producing organism
Streptomyces sp.
Biological activity
protein tyrosine phosphatase inhibitor
Phosphatoquinones A and B were isolated from the cultured broth of Streptomyces sp. TA-0363 and their structures were elucidated by spectroscopic analyses. Phosphatoquinones A and B inhibited the protein tyrosine phosphatase activity prepared from human Ball-1 cells with IC50 of 28 µM and 2.9 µM, respectively.
isolation and structural determination
  • Kagamizono T, Hamaguchi T, Ando T, Sugawara K, Adachi T, Osada H.: Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.
    J Antibiot, 52(2): 75-80 (1999) PMID: 10344559
  • Additional information