Phosphatoquinone A, B
- Structure
-
A:
B:
- Producing organism
- Streptomyces sp.
- Biological activity
- protein tyrosine phosphatase inhibitor
- Abstract
- Phosphatoquinones A and B were isolated from the cultured broth of Streptomyces sp. TA-0363 and their structures were elucidated by spectroscopic analyses. Phosphatoquinones A and B inhibited the protein tyrosine phosphatase activity prepared from human Ball-1 cells with IC50 of 28 µM and 2.9 µM, respectively.
- References
-
isolation and structural determination
- Kagamizono T, Hamaguchi T, Ando T, Sugawara K, Adachi T, Osada H.: Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.
J Antibiot, 52(2): 75-80 (1999)
- Kagamizono T, Hamaguchi T, Ando T, Sugawara K, Adachi T, Osada H.: Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.