NPEdia Phosmidosine
Producing organism
Streptomyces sp. RK-16
Biological activity
antifungal activity
A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 µg/ml.
isolation and structural determination
  • Uramoto M, Kim CJ, Shin-Ya K, Kusakabe H, Isono K, Phillips DR, McCloskey JA.: Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.
    J Antibiot, 44(4): 375-381 (1991) PMID: 2032945
  • Matsuura N, Onose R, Osada H.: Morphology reversion activity of phosmidosine and phosmidosine B, a newly isolated derivative, on src transformed NRK cells.
    J Antibiot, 49(4): 361-365 (1996) PMID: 8641999
  • biological activities
  • Kakeya H, Onose R, Liu PC, Onozawa C, Matsumura F, Osada H.: Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic.
    Cancer Res, 58(4): 704-710 (1998) PMID: 9485024
  • Additional information