Linearolide A and B

A: NPEdia

B: NPEdia
Producing organism
Streptomyces sp. RK95-74
Biological activity
weak cytotoxicity
Although all Streptomyces strains are now thought to have 20-30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.
  • Ueki M, Koshiro N, Aono H, Kawatani M, Uramoto M, Kawasaki H, Osada H.: Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74.
    J Antibiot, 66(6): 333-337 (2013) PMID: 23531987 [ doi: 10.1038/ja.2013.19 ]
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