Epoxytwinol A
- Structure
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- Producing organism
- unidentified fungus
- Biological activity
- antiangiogenesis
- Abstract
- We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C2 symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED100= 2.6 µM).
- References
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isolation and structural determination
- Kakeya H, Onose R, Koshino H, Osada H.: Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
Chem Commun (Camb), (20): 2575-2577 (2005)
[ doi: 10.1039/b501392e ] - Kakeya H, Onose R, Koshino H, Osada H.: Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.