Epoxytwinol A

NPEdia Epoxytwinol A
Producing organism
unidentified fungus
Biological activity
We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C2 symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED100= 2.6 µM).
isolation and structural determination
  • Kakeya H, Onose R, Koshino H, Osada H.: Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
    Chem Commun (Camb), (20): 2575-2577 (2005) PMID: 15900331 [ doi: 10.1039/b501392e ]
  • Additional information