Cytotrienin A, B

A: NPEdia
B: NPEdia
Producing organism
Streptomyces sp. RK95-74
Biological activity
cytotoxic, apoptosis inducing activity
Cytotrienin A and B, two novel triene-ansamycins containing a unique 1-aminocyclopropane carboxylic acid moiety, were isolated from the culture broth of Streptomyces sp. through a separation procedure guided by the cytotoxic activity in vitro. The structures were elucidated on the basis of spectroscopic data. Cytotrienins A nad B exhibited a potent apoptosis-nducing actibity on human leukemia HL-60 cells.
isolation and structural determination
  • Zhang HP, Kakeya H, Osada H.
    Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells.
    Tetrahedron Letter 38, 1789-1792 (1997) [ doi: 10.1016/S0040-4039(97)00170-6 ]
  • Kakeya H, Zhang HP, Kobinata K, Onose R, Onozawa C, Kudo T, Osada H.: Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
    J Antibiot, 50(4): 370-372 (1997) PMID: 9186568
  • biosynthetic studies
  • Zhang HP, Kakeya H, Osada H.
    Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.
    Tetrahedron Letter 39, 6947-6948 (1998) [ doi: 10.1016/S0040-4039(98)01460-9 ]
  • biological activities
  • Kakeya H, Onose R, Osada H.: Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
    Cancer Res, 58(21): 4888-4894 (1998) PMID: 9809995
  • Watabe M, Kakeya H, Onose R, Osada H.: Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
    J Biol Chem, 275(12): 8766-8771 (2000) PMID: 10722720
  • Additional information