NPEdia Curvularol Curvularia sp. RK97-F166
Producing organism
Curvularia sp. RK97-F166 (isolated in Nagasaki, Japan)
Biological activity
eucaryotic protein synthesis inhitibion
A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no antibacterial activity, and very weak antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G1 phase at 150 ng/ml. Curvularol induced the morphological reversion of srcts-transformed NRK cells at 100 ng/ml, and inhibited protein synthesis same as cycloheximide.
isolation and structural determination
  • Honda Y, Ueki M, Okada G, Onose R, Usami R, Horikoshi K, Osada H.: Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166.
    J Antibiot, 54(1): 10-16 (2001) PMID: 11269706
  • Additional information