Albopeptin B
- Structure
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- Producing organism
- Streptomyces albofaciens
- Biological activity
- antimicrobial activity
- Abstract
- Antibiotics albopeptin A and B were purified from cultures of Streptomyces albofaciens by Nucleosil 5C18 HPLC. The formulas of albopeptin A and B were C41H67N11O12S and C40H65N11O12S, resp. IR spectra of albopeptins A and B. They were sol. in formic acid and trifluoroacetic acid. Albopeptins A and B showed broad antibacterial and antifungal activities. A mixt. of albopeptins A and B prevented the sheath blight disease in rice plants. Mice tolerated a mixt. of albopeptins A and B at 600 mg/kg.
- References
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isolation and structural determination
- Isono K, Kobinata K, Oikawa H, Kusakabe H, Uramoto M, Ko K, Misato T, Tai SW, Ni CT, Shen YC.
New antibiotics, albopeptins A and B.
Agric. Biol. Chem. 50, 2163-2165 (1986) [ doi: 10.1271/bbb1961.50.2163 ]synthesis by other group- Oikawa H, Fukushi E, Nishitoba T, Ichihara A, Kobinata K, Isono K.
The structures of peptide antibiotics, albopeptin B and its analog.
Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 34, 574-581 (1992) [ J-GLOBAL ID: 200902051683752890 ]biosynthesis and structural determination- Hideaki Oikawa, Yusuke Mizunoue, Takemichi Nakamura, Eri Fukushi, Jiang Yulu, Taro Ozaki, Atsushi Minami.
Structure and biosynthesis of the ribosomal lipopeptide antibiotic albopeptins
Bioscience, Biotechnology, and Biochemistry. [Epub ahead of print] (2022) [ doi: 10.1093/bbb/zbac039 ] - Isono K, Kobinata K, Oikawa H, Kusakabe H, Uramoto M, Ko K, Misato T, Tai SW, Ni CT, Shen YC.
This structure has been corrected by the reference.(April 5, 2022)