Producing organism
Streptomyces pulveraceus subsp. epiderstagenes
Biological activity
mitogenic activity
A new glutarimide antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 mM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-[1H] NOE's techniques.
isolation and structural determination
  • Sonoda T, Osada H, Uzawa J, Isono K.: Actiketal, a new member of the glutarimide antibiotics.
    J Antibiot, 44(2): 160-163 (1991) PMID: 2010356
  • synthesis by other group
  • Kiyota H, Shimizu Y, Oritani T.
    Synthesis of actiketal, a glutarimide antibiotic.
    Tetrahedron Lett. 41, 5887-5890 (2000) [ doi: 10.1016/S0040-4039(00)00928-X ]
  • Additional information