Reveromycin A

Structure

• InChI=1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29?,30?,35+,36-/m0/s1
• InChIKey=ZESGNAJSBDILTB-FAKCWQBJSA-N

Synonyms

• 134615-37-5

Origin

Streptomyces reveromyceticus

Biological activities

epidermal growth factor inhibitor (Eukaryota)
Inhibition of eukaryotic protein synthesis (Eukaryota)
protein synthesis inhitibion (Eukaryota)

Therapeutic

Anticancer
Antifungal
Osteoporosis

Target

Ile-tRNA synthase (IleRS)

Assay information

Inhibition of isoleucyl-tRNA synthetase (IC₅₀ = 2-12 nM)
Inhibition of protein synthesis in eukaryotic cells (IC₅₀ = 40 nM)
Growth inhibition against osteoclasts (IC₅₀ = 0.2 μM)
Growth inhibition against cancer cells (IC₅₀ [μM]): KB (3) K562 (3), HL60 (20), HeLa (78)
Antifungal activity (MIC [μM]): C. albicans (3.7, pH3)