FSL0410

Structure

• InChI=1S/C12H18N2O7/c1-6-3-4-21-12(7(16)10(2,19)5-15)9(18)13-11(6,20)8(17)14-12/h7,15-16,19-20H,1,3-5H2,2H3,(H,13,18)(H,14,17)/t7-,10-,11+,12?/m0/s1
• InChIKey=WOUDXEYYJPOSNE-KJRDOUMZSA-N

Synonyms

• 38129-37-2
• 5879
• 89362-24-3
• Aizumycin
• Bicozamycin
• Bicyclomycin
• WS-4545

Origin

Streptomyces sp.

Biological activities

Inhibition of Rho

Therapeutic

Antibiotics

Target

Rho

Assay information

Antibacterial activities against Gram-negative bacteria (MIC values: 12.5 ~ 50 μg/ml against E. coli, Sh. flexneri, Sh. sonnei, Salm. typhosa, Salm. paratyphi, Salm. typhimurium, and Salm. enteritidis)
Inactive against Gram-positive bacteria, such as Staph. aureus, Strept. hemolyticus, Dipl. pneumoniae, Coryn. diphtheriae, and Mycob. tuberculosis at MIC value of 800 μg/ml
Decreases in the release of inorganic phosphate (IC₅₀: 60-70 μM)
Inhibits Rho by being a reversible, noncompetitive inhibitor of ATP