FSL0406

Structure

• InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13?,14+/m1/s1
• InChIKey=VGGGPCQERPFHOB-YIOYIWSBSA-N

Synonyms

• (-)-Bestatin
• 58970-76-6
• Bestatin
• NK 421
• NSC 265489
• Ubenimex

Origin

Streptomyces olivoreticuli

Biological activities

Inhibition of aminopeptidase B

Therapeutic

Anticancer

Target

Aminopeptidase B

Assay information

Bestatin competitively inhibits leucine aminopeptidase with IC₅₀ value of 0.01 μg/mL and shows the growth inhibitory activity against human leukemic cell lines (P39/TSU, HL60, U937, THP1, K562; IC₅₀ = 0.48-6.4 μg