(+)-Staurosporine
- Structure
- InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
- InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N
- Synonyms
-
- AM-2282
- Antibiotic 230
- Antibiotic AM 2282
- CGP 39360
- Staurosporin
- Staurosporin
- Staurosporine
- Origin
- Actinomycete N96C-47
Lentzea albida
- Biological activities
- Broad kinase inhibition
- Therapeutic
-
Anticancer
Antifungal
- Target
-
Protein kinases
- Assay information
-
Inhibition of several kinds of protein kinases (IC50 [nM]): protein kinase C (2.7), protein kinase A (22), protein kinase G (8.5), tyrosine kinase (6.4), myosin light chain kinase (5), cdc2 (4)
Cytotoxicity (IC50 [μM]): HeLa S3 cells (0.28)
Antibacterial activity (MIC [μg/ml]): C. albicans (6.25), A. fumigatus (12.5)